Anti-p16INK4a/CDKN2 antibody (monoclonal) | MyBioSource MBS175053 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-p16INK4a/CDKN2 antibody (monoclonal)

catalog :

MBS175053

quantity :

0.1 mg

price :

245 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

IMD-16

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175053

products type :

Antibody

products full name :

Anti-p16INK4a/CDKN2 antibody (monoclonal)

products short name :

p16INK4a/CDKN2

products name syn :

Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase inhibitor 2A; ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A; CDK4 INHIBITOR; cyclin-dependent kinase inhibitor 2A(melanoma, p16, inhibits CDK4); Cyclin-dependent kinase 4 inhibitor A; Multiple tumor suppressor 1; Collaborator of ARF

other names :

Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase inhibitor 2A; CDK4 inhibitor p16-INK4; multiple tumor suppressor 1; cell cycle negative regulator beta; CDKN2A {ECO:0000312 EMBL:AAM77919.1}; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4A

products gene name :

CDKN2A

other gene names :

CDKN2A; CDKN2A; ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A; CDKN2; MTS1; CDK4I; MTS-1; p16-INK4; p16INK4A

uniprot entry name :

CD2A1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

IMD-16

host :

Mouse

reactivity :

Human

sequence length :

156

purity :

Ascites

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Formalin, Immunocytochemistry (ICC)

other info1 :

Immunogen: Recombinant human p16 protein.

other info2 :

Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

products description :

Description: Mouse IgG monoclonal antibody for p16INK4a/CDKN2, cyclin-dependent kinase inhibitor 2A (CDKN2A) detection. Tested with WB, IHC-F, ICC in Human. No cross reactivity with other proteins. Uniprot ID: P42771. Background: p16(INK4A), also known as cyclin-dependent kinase inhibitor 2A(CDKN2A), or multiple tumor suppressor 1(MTS1). The p16 gene(CDKN2A) was mapped to 9p21. The p16 gene encodes a negative regulator of the cell cycle. CDKN2 plays an important role during tumorigenesis or tumor progression in a significant proportion of pancreatic adenocarcinomas. Germ-line mutations in the CDKN2A tumor-suppressor gene have been linked to the development of melanoma in some families with inherited melanoma.

ncbi gi num :

3041660

ncbi acc num :

P42771.2

uniprot acc num :

P42771

ncbi mol weight :

8,731 Da

ncbi pathways :

Apoptosis Pathway 198797!!Apoptosis Modulation And Signaling Pathway 198822!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Cell Cycle Pathway 198811!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Cellular Senescence Pathway 905991

ncbi summary :

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

size :

0.1 mg

price :

245 USD

more info or order :

MyBioSource product webpage