antibody

Anti-p19INK4d antibody (monoclonal)

MBS175038

0.1 mg

245 USD

monoclonal

mouse

nonconjugated

IMD-19

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

Antibody

Anti-p19INK4d antibody (monoclonal)

p19INK4d

Cyclin-dependent kinase 4 inhibitor D; cyclin-dependent kinase inhibitor 2D(p19, inhibits CDK4); INK4D; p19; p19-INK4d

Cyclin-dependent kinase 4 inhibitor D; Cyclin-dependent kinase 4 inhibitor D; cyclin-dependent kinase 4 inhibitor D; CDK inhibitor p19INK4d; inhibitor of cyclin-dependent kinase 4d; cyclin-dependent kinase 4 inhibitor D p19; cell cycle inhibitor, Nur77 associating protein; cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); p19-INK4d

CDKN2D

CDKN2D; CDKN2D; p19; INK4D; p19-INK4D

CDN2D_HUMAN

Monoclonal

IgG1

IMD-19

Mouse

Human

166

Ascites

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

Immunogen: Recombinant human p19INK4d.

Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Description: Mouse IgG monoclonal antibody for p19INK4d, cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) (CDKN2D) detection. Tested with WB, IHC-P, ICC in Human. No cross reactivity with other proteins. Uniprot ID: P55273. Background: Cyclins are important in regulating the cell cycle through their formation of enzymatic complexes with various cyclin-dependent kinases. P19(INK4d) also kowns as cyclin-dependent kinase inhibitor 2D, is one of the novel members of the mouse INK4 gene family. Okuda et al.(1995) described the cloning of the human INK4d gene(CDKN2D). The predicted 166-amino acid protein is 86% identical to the mouse protein and about 45% identical to other human INK4 family members.

1705730

P55273.1

P55273

17,700 Da

Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Cellular Senescence Pathway 905991!!Cellular Responses To Stress Pathway 645258!!Cyclin D Associated Events In G1 Pathway 105767!!FoxO Signaling Pathway 921162!!G1 Phase Pathway 105766!!G1 To S Cell Cycle Control Pathway 198805

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

0.1 mg

245 USD