catalog number :
MBS175033
products full name :
Anti-PSTAIR antibody (monoclonal)
products short name :
PSTAIR
products name syn :
Cyclin-dependent kinase 1; cyclin-dependent kinase 1; CDC2; CDC28A; CDKN1; P34CDC2; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase
other names :
Cyclin-dependent kinase 1; Cyclin-dependent kinase 1; cyclin-dependent kinase 1; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; cyclin-dependent kinase 1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase
products gene name :
CDK1
other gene names :
CDK1; CDK1; CDC2; CDC28A; P34CDC2; CDC2; CDC28A; CDKN1; P34CDC2; CDK1
uniprot entry name :
CDK1_HUMAN
reactivity :
Human, mouse
storage stability :
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
tested application :
Western Blot (WB)
other info1 :
Immunogen: Synthetic 16 amino acid oligopeptide containing the PSTAIR sequence conjugated to BSA.
other info2 :
Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
products description :
Description: Mouse IgG monoclonal antibody for PSTAIR, cyclin-dependent kinase 1 (CDK1) detection. Tested with WB in Human, mouse. No cross reactivity with other proteins. Uniprot ID: P06493. Background: The cyclin-dependent protein kinases(CDKs) regulate major cell cycle transitions in eukaryotic cells. CDKs contain an evolutionary conserved 16 amino acid sequence called PSTAIR(EGVPSTAIREISLLKE) which distinguishes them from other protein kinases. The PSTAIRE motif found in prototypic CDC2 kinases. CDC2L1 is referred as PITSLRE B, based on the amino acid sequence of the region corresponding to the conserved CDC2 PSTAIRE box.
ncbi mol weight :
27,503 Da
ncbi pathways :
APC/C-mediated Degradation Of Cell Cycle Proteins Pathway 105825!!APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway 105832!!APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway 105831!!ARMS-mediated Activation Pathway 106466!!Activated TLR4 Signalling Pathway 106400!!Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway 105829!!Activation Of NIMA Kinases NEK9, NEK6, NEK7 Pathway 771571!!Axon Guidance Pathway 105688!!Cell Cycle Pathway 530733!!Cell Cycle Checkpoints Pathway 105739
ncbi summary :
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]