Anti-Mucin Gastric Antibody (Monoclonal, 45M1) | MyBioSource MBS175024 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Mucin Gastric Antibody (Monoclonal, 45M1)

catalog :

MBS175024

quantity :

0.1 mg

price :

245 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

45M1

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS175024

products type :

Antibody

products full name :

Anti-Mucin Gastric Antibody (Monoclonal, 45M1)

products short name :

Mucin-5AC

products name syn :

mucin 5AC, oligomeric mucus/gel-forming

other names :

Mucin-5B; Mucin-5B; mucin-5B; cervical mucin MUC5B; sublingual gland mucin; mucin 5, subtype B, tracheobronchial; high molecular weight salivary mucin MG1; mucin 5B, oligomeric mucus/gel-forming; Cervical mucin; High molecular weight salivary mucin MG1; Mucin-5 subtype B, tracheobronchial; Sublingual gland mucin

products gene name :

MUC5C

other gene names :

MUC5B; MUC5B; MG1; MUC5; MUC9; MUC-5B; MUC5; MUC-5B

uniprot entry name :

MUC5B_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

45M1

host :

Mouse

reactivity :

Human, Mouse, Rat, Rabbit

sequence length :

5762

purity :

Ascites

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

app notes :

Western blot: 1-2ug/ml; Immunohistochemistry (Paraffinembedded Section): 2-4ug/ml; Immunocytochemistry: 1ug/ml

other info1 :

Immunogen: Mucin from human ovarian cyst fluid.

other info2 :

Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

products description :

Mucin 5AC (Muc5AC) is a protein that in humans is encoded by the MUC5AC gene. Using real-time RT-PCR, Moehle et al. (2006) found that MUC5AC was highly expressed in adult trachea and stomach. Expression was lower in adult lung and weak in fetal lung, and no expression was detected in other tissues. This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease. Moreover, Muc5ac is identified as a direct and critical mediator of resistance during intestinal nematode infection.

ncbi gi num :

308153579

ncbi acc num :

Q9HC84.3

uniprot acc num :

Q9HC84

ncbi mol weight :

596,340 Da

ncbi pathways :

Metabolism Of Proteins Pathway (106230); O-linked Glycosylation Pathway (980459); O-linked Glycosylation Of Mucins Pathway (530747); Post-translational Protein Modification Pathway (161012); Salivary Secretion Pathway (153376); Salivary Secretion Pathway (153352); Termination Of O-glycan Biosynthesis Pathway (530748)

ncbi summary :

This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]

uniprot summary :

MUC5B: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Defects in MUC5B are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF). Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741). Protein type: Cell adhesion; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: extracellular space; Golgi lumen. Molecular Function: protein binding. Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; regulation of macrophage activation; defense response to bacterium; post-translational protein modification. Disease: Pulmonary Fibrosis, Idiopathic

size1 :

0.1 mg

price1 :

245 USD

more info or order :

MyBioSource product webpage