protein

Pepsinogen II (PGII/PGC), Human Gastric Mucosa

MBS173574

0.1 mg

390 USD

Protein

Pepsinogen II (PGII/PGC), Human Gastric Mucosa

[Pepsinogen II]

[Pepsinogen C; PG II; PGC; Gastricsin; Pepsinogen II (PGII, PGC) - >=90% (SDS-PAGE) - Lyophilized]

[Gastricsin; Gastricsin; gastricsin; pepsin C; pepsinogen C; preprogastricsin; pepsinogen group II; progastricsin (pepsinogen C); Pepsinogen C]

[PGC]

[RP11-298J23.1; PEPC; PGII]

[PGC; PGC; PEPC; PGII]

PEPC_HUMAN

Human gastric mucosa

315

>= 90% (SDS-PAGE) may contain minor cleavage products.

Powder, lyophilized from tris chloride, pH 8.5

Store at -20°C.

Western Blot (WB)

Appearance: White to off-white powder. Solubility: Clear, colorless (1mg/mL 0.02 M Tris-Chloride, pH= 8.0 buffer). Protein: 1.4 mg protein /vial (E 0.1% 280nm= 1.43). Specific Activity: 2,920 U/mg protein (after activation). Unit Definition: One unit will produce a change in A280 of 0.001 per minute at pH 2.0 and 37°C, measured as TCA-soluble products from hemoglobin. Identity: Confirmed by Western Blot.

Handling: Handle as a potentially hazardous substance. Reconstitution: After reconstitution maintain at or above pH 8.0 to avoid activation.

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Pepsinogen Ii (pgii; Pgc)

MyBioSource is the leading producer and supplier of Human Pepsinogen II/C antigen as a stomach gastric cancer marker for medical research, clinical and diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of porteins after activation of acidic pH. Pepsinogen is synthesized as isoymogens and are classified into two groups, I and II.

129796

P20142.1

P20142

40,600

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

PGC: Hydrolyzes a variety of proteins. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Protease; Secreted; EC 3.4.23.3. Chromosomal Location of Human Ortholog: 6p21.1. Cellular Component: extracellular space. Molecular Function: aspartic-type endopeptidase activity. Biological Process: digestion; proteolysis

0.1 mg

390 USD

1 mg

805