catalog number :
MBS173573
products full name :
Pepsinogen I (PGI/PGA), Human Stomach
products short name :
Pepsinogen I
products name syn :
Pepsinogen I (PGI, PGA) - >=90% (SDS-PAGE) - Lyophilized
products gene name :
PGA3
products gene name syn :
PGA4; PGA5
purity :
>= 90% (SDS-PAGE, may contain minor cleavage products)
form :
Powder, Lyophilized from tris chloride, pH8.5. Appearance: White lyophilisate
storage stability :
At -20 degree C
tested application :
Western Blot (WB)
other info1 :
Source: Human Gastric Mucosa. EC Number: 3.4.23.1. Unit Definition: One unit will produce a change A280 of 0.001 per minute at pH 2.0 and 37 degree C, measured as TCA-soluble products from hemoglobin. Solubility: Clear, Colorless (1mg/mL saline)
other info2 :
Reconstitution: 1 mg/mL saline (Clear, colorless). Recertification: 10-30-2016. Protein: 0.1mg protein/vial (E 0.1% 280nm =1.48). Specific Activity: 3,700 U/mg protein (after activation)
products categories :
Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Pepsinogen I (pgi; Pga)
products description :
MyBioSource is the leading producer and supplier of human gastric Pepsinogen I (A) antigen as a cancer marker for medical research, clinical and biomedical manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of proteins after activation of acidic pH. It is synthesized as isoymogens and are classified into two groups, Pepsinogen I and Pepsinogen II). Human PGA and PGC antigen have been investigated as a possible biomarker for early detection of, Gastric cancer (GC), adenoma (GA) and severe atrophic (diffuse or patchy) corpus gastritis. It has been reported that human Pepsinogen I (PGA) levels were lower in atrophic corpus gastritis than in atrophic antral gastritis, and human pepsinogen I(PGA) levels were lower in advanced gastric cancer than early stage gastric cancer.