Alpha-2 Antiplasmin, Human Plasma | MyBioSource MBS173533 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Alpha-2 Antiplasmin, Human Plasma

catalog :

MBS173533

quantity :

0.1 mg

price :

240 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173533

products type :

Protein

products full name :

Alpha-2 Antiplasmin, Human Plasma

products short name :

[Alpha-2 Antiplasmin]

products name syn :

[Alpha-2-AP, Alpha-2-plasmin inhibitor, alpha 2-antiplasmin; Plasmin Inhibitor; Alpha-2 Antiplasmin (A2AP).]

other names :

[alpha-2-antiplasmin isoform a; Alpha-2-antiplasmin; alpha-2-antiplasmin; serpin F2; alpha-2-AP; alpha-2-plasmin inhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Alpha-2-plasmin inhibitor; Alpha-2-PI; Serpin F2]

products gene name :

[A2AP]

other gene names :

[SERPINF2; SERPINF2; AAP; API; PLI; A2AP; ALPHA-2-PI; AAP; PLI; Alpha-2-AP; Alpha-2-PI]

uniprot entry name :

A2AP_HUMAN

sequence length :

491

purity :

>= 95% (SDS-PAGE)

form :

Powder, lyophilized form 20mM Bis-Tris, 200 mM sodium chloride, pH 6.4

storage stability :

Storage: At -20°C. Storage Note: Protect from moisture. Shipping note: Cold pack

other info1 :

Source: Human Plasma. Specific Activity: >= 17 U/mg protein. Unit definition: One alpha-2-antiplasmin unit inhibits one unit of plasmin( catalyzing the hydrolysis of one micromole of tosyl-Gly-Pro-Lys-pNA per minute at pH 8.0 and 25°C. Handling: Handle as a potentially hazardous substance.

other info2 :

. Protein: 1mg/vial (E 0.1% 280nm =0.70)

products categories :

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Alpha-2 Antiplasmin (a2ap)

products description :

MyBioSource is a leading supplier of human plasma Alpha-2 Antiplasmin for research and diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Alpha-2 Antiplasmin (A2AP) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins. In liver cirrhosis, there is decreased production of alpha-2 antiplasmin, leading to lowered inactivation of plasmin and an increase in fibrinolysis. This is associated with an increase risk of bleeding in liver disease.

ncbi gi num :

115583663

ncbi acc num :

NP_000925.2

ncbi gb acc num :

NM_000934.3

ncbi mol weight :

58,700

ncbi pathways :

Blood Clotting Cascade Pathway (198840); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Dissolution Of Fibrin Clot Pathway (106061); Hemostasis Pathway (106028); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)

ncbi summary :

This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

uniprot summary :

SERPINF2: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID). APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis. Belongs to the serpin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 17p13. Cellular Component: extracellular space; cell surface; fibrinogen complex; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protein homodimerization activity; protease binding; endopeptidase inhibitor activity. Biological Process: platelet activation; collagen fibril organization; positive regulation of smooth muscle cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; response to organic substance; fibrinolysis; negative regulation of fibrinolysis; platelet degranulation; renin-angiotensin regulation of blood vessel size; positive regulation of stress fiber formation; acute-phase response; blood vessel morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; blood coagulation. Disease: Alpha-2-plasmin Inhibitor Deficiency

size1 :

0.1 mg

price1 :

240 USD

size2 :

1 mg

price2 :

875

more info or order :

MyBioSource product webpage