Osteopontin, Human Breast Milk | MyBioSource MBS173394 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Osteopontin, Human Breast Milk

catalog :

MBS173394

quantity :

0.025 mg

price :

275 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173394

products type :

Protein

products full name :

Osteopontin, Human Breast Milk

products short name :

Osteopontin

products name syn :

Osteopontin; OPN; BNSP; Osteopontin (OPN), Human Milk

other names :

osteopontin; Osteopontin; osteopontin; uropontin; nephropontin; SPP1/CALPHA1 fusion; urinary stone protein; early T-lymphocyte activation 1; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); secreted phosphoprotein 1; Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin

other gene names :

SPP1; SPP1; OPN; BNSP; BSPI; ETA-1; BNSP; OPN; SPP-1

uniprot entry name :

OSTP_HUMAN

sequence length :

300

purity :

>= 95% (SDS-PAGE, multiple bands 40-60 kDa, representing variants in glycosylation)

form :

Solution in 10mM Sodium Phosphate, 150mM sodium chloride, and 0.1% sodium azide, pH7.2.

storage stability :

At -20 degree C. Shipping: Ships with Dry Ice

tested application :

ELISA (EIA)

other info1 :

Source: Human Breast Milk. Appearance: Frozen liquid. Protein: 1.7mg/ml (E 0.1% 280nm =0.67)

other info2 :

Recertification: 2 years. Protein: 1.7 mg/mL (A280 E = 0.67)

products categories :

Proteins; Antigens; Standards/controls; Native Proteins; Osteopontin (opn)

products description :

Custom preparations, technical support, bulk quantities and aliquoting available. Research has been found that OPN interacts with multiple cell surface receptors which are ubiquitously expressed making it an active player in many physiological and pathological processes including wound healing, bone turnover, tumorigenesis, inflammation, ischemia and immune responses. Therefore studies have shown that manipulation of plasma OPN levels may be useful in the treatment of autoimmune diseases, cancer metastasis, osteoporosis and some forms of stress. Osteopontin has been implicated in autoimmune diseases such as rheumatoid arthritis, autoimmune hepatitis, and multiple sclerosis. According to current research Osteopontin has also been associated with allergic inflammation and asthma, plays a number of roles in the diseases of skeletal muscles and has been found to be overexpressed in a variety of cancers such as lung cancer, breast cancer, colorectal cancer, stomach cancer and ovarian cancer.

ncbi gi num :

189405

ncbi acc num :

AAA59974.1

ncbi mol weight :

40,000 - 60,000 (glycosylation)

ncbi pathways :

BDNF Signaling Pathway (712093); Degradation Of The Extracellular Matrix Pathway (576263); Direct P53 Effectors Pathway (137939); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (576262); FGF Signaling Pathway (137989); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067)

ncbi summary :

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

uniprot summary :

osteopontin: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Belongs to the osteopontin family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q22.1. Cellular Component: extracellular space; cell projection; perinuclear region of cytoplasm; apical part of cell; extracellular region. Molecular Function: protein binding; extracellular matrix binding; cytokine activity. Biological Process: osteoblast differentiation; extracellular matrix disassembly; neutrophil chemotaxis; extracellular matrix organization and biogenesis; response to vitamin D; response to steroid hormone stimulus; biomineral formation; negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of bone resorption; decidualization; inflammatory response; cell adhesion; embryo implantation

size1 :

0.025 mg

price1 :

275 USD

size2 :

0.1 mg

price2 :

600

size3 :

1 mg

price3 :

2115

more info or order :

MyBioSource product webpage