protein

Lactoferrin (Lf), Bovine Milk

MBS173354

0.1 mg

140 USD

Protein

Lactoferrin (Lf), Bovine Milk

[Lactoferrin]

[Lactoferrin (Lf), Bovine]

[lactoferrin; Lactotransferrin; lactotransferrin; kaliocin-1; lactoferricin; lactoferroxin; talalactoferrin; neutrophil lactoferrin; growth-inhibiting protein 12; epididymis luminal protein 110; lactotransferrin; Growth-inhibiting protein 12; TalalactoferrinCleaved into the following 5 chains:Lactoferricin-H; Lfcin-H; Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C]

[LTF; LTF; LF; HLF2; GIG12; HEL110; GIG12; LF; Lactoferrin; Lfcin-H]

TRFL_HUMAN

711

>= 95% (SDS-PAGE)

Liquid in 10 mM sodium phosphate, 150mM sodium chloride, pH 7.2, with 0.09% sodium azide.

At -20°C . Avoid freeze-thaws. Ships with dry ice.

Source: Bovine Milk

Protein: 5.3 mg/mL (A 280 ). Handling: Handle as a potentially hazardous substance. Recovery: If small volume, microfuge vial before drawing from container.

Proteins; Antigens; Standards/controls; Native Proteins; Lactoferrin (lf)

MyBioSource produces bulk quantities of high purity Bovine Milk Lactoferrin for IVD manufacturing or research/laboratory use. Custom preparations, technical support, bulk quantities and aliquoting available.

187122

AAA59511.1

78,000

Amyloids Pathway (366238); Disease Pathway (530764); Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway (645267); Mtb Iron Assimilation By Chelation Pathway (1127564); Phagosomal Maturation (early Endosomal Stage) Pathway (645268); Response Of Mtb To Phagocytosis Pathway (1127560)

This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

LTF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Belongs to the transferrin family. 2 isoforms of the human protein are produced by alternative promoter. Protein type: Secreted, signal peptide; Secreted; Protease; EC 3.4.21.-. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: extracellular space; specific granule; cytoplasm; extracellular region; nucleus; secretory granule. Molecular Function: heparin binding; protein serine/threonine kinase activator activity; protein binding; DNA binding; ferric iron binding; iron ion binding; serine-type endopeptidase activity. Biological Process: negative regulation of lipopolysaccharide-mediated signaling pathway; interaction with host; ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; positive regulation of toll-like receptor 4 signaling pathway; antifungal humoral response; proteolysis; iron ion transport; humoral immune response; activation of NF-kappaB transcription factor; regulation of cytokine production; positive regulation of osteoblast differentiation; retinal homeostasis; innate immune response in mucosa; negative regulation of viral genome replication; response to host immune response; positive regulation of osteoblast proliferation; antibacterial humoral response; regulation of tumor necrosis factor production; negative regulation of ATPase activity; iron assimilation by chelation and transport; negative regulation of viral reproduction; negative regulation of apoptosis

0.1 mg

140 USD

1 mg

230

10 mg

715