catalog number :
MBS173334
products full name :
Tropomyosin, Human Heart
products short name :
Tropomyosin
products name syn :
Tropomyosin (TPM)
other names :
tropomyosin; tropomyosin
purity :
>= 95% (SDS-PAGE)
form :
Lyophilized. Appearance: White powder
storage stability :
At -20 degree C
other info1 :
Source: Human Heart. EC Number: 2.7.22.28
other info2 :
Reconstitution: Use a neutral pH buffer of users choice, avoiding extreme high and low pH. Recertification: 3 years. Protein: >= 1.0 mg protein/mg solid (A280 E=0.274)
products categories :
Proteins; Antigens; Standards/controls; Native Proteins; Tropomyosin (tpm)
products description :
MyBioSource is the leading supplier of Human Heart Tropomyosin (TPM) for medical research and diagnostic manufacturing. Technical support, bulk quantities, and custom buffers and aliquots are available. TROPOMYOSIN is an actin-binding protein that regulates actin mechanics. Tropmyosin is important, among other things, for muscle contraction. Tropomyosin, along with the troponin complex, associate with actin in muscle fibers and regulate muscle contraction by regulating the binding of myosin. In resting muscle, tropomyosin overlays the myosin binding sites on actin and is "locked" down in this position by troponin T (tropomyosin binding troponin) and troponin I (inhibitory troponin). Upon release of calcium from the sarcoplasmic reticulum calcium binds to troponin C (calcium binding troponin). This "unlocks" tropomyosin from actin, allowing it to move away from the binding groove. Myosin heads can now access the binding sites on actin. Once one myosin head binds, this fully displaces tropomyosin and allows additional myosin heads to bind, initiating muscle shortening and contraction. Once calcium is pumped out of the cytoplasm and calcium levels return to normal, tropomyosin again binds to actin, preventing myosin from binding.
ncbi acc num :
NP_001081599.1
ncbi gb acc num :
NM_001088130.1
ncbi mol weight :
~70,000