MyBioSource

protein

Haptoglobin, Horse Serum

MBS173327

0.1 mg

200 USD

MBS173327

Protein

Haptoglobin, Horse Serum

Haptoglobin

Haptoglobin (Hp), Equine

haptoglobin; Haptoglobin; haptoglobin; zonulin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide; haptoglobin; ZonulinCleaved into the following 2 chains:Haptoglobin alpha chain; Haptoglobin beta chain

HP; HP; BP; HPA1S; HP2ALPHA2; N/A

HPT_HUMAN

406

>= 90% (SDS-PAGE)

Liquid

> 0.5 mg/mL (A280)

At -20 degree C

Source: Equine Serum

Recertification: 2 years. pH: Typically 7.0

Proteins; Antigens; Standards/controls; Native Proteins; Haptoglobin (hp)

Custom preparations, technical support, bulk quantities and aliquoting available. Haptoglobin (frequently abbreviated as Hp) is a protein in the blood plasma that binds free hemoglobin released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). Haptoglobin is a serum protein that consists of two alpha and two beta chains connected by disulfide bridges. It acts as a hemoglobin scavenger and has been associated with protease inhibitory activity. EQUINE HAPTOGLOBIN is a positive acute phase reactant, the levels of which increase significantly in horses in response to inflammation, tissue injury or disease.

386783

AAA88080.1

38,452 Da

Binding And Uptake Of Ligands By Scavenger Receptors Pathway 771599!!Scavenging Of Heme From Plasma Pathway 771600!!Amb2 Integrin Signaling Pathway 137945

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

0.1 mg

200 USD