catalog number :
MBS173258
products full name :
Cytochrome C, Horse Heart - High Purity
products short name :
Cytochrome C
products name syn :
Cytochrome C (CYT C), Horse Heart - High Purity
other names :
cytochrome c; Cytochrome c; cytochrome c; cytochrome c, somatic
other gene names :
CYCS; CYCS; CYC; HCS; THC4; CYC
uniprot entry name :
CYC_HUMAN
form :
Lyophilized. Appearance: Reddish to dark brown powder
storage stability :
2-8 degree C. Ship with cold packs
other info1 :
Source: Horse Heart. Iron: 0.42%
other info2 :
Solubility: Clear and red. Recertification: 10-08-2016. pH: 5.0 - 7.0. Iron Assay: < 0.50%. CAS Number: 9007-43-6. Total bacteria: 80 CFU/g. Water: 5.6%. E.Col: Not Detected. Salmonella: Not Detected. Molds & Yeast: Not Detected
products categories :
Proteins; Antigens; Standards/controls; Native Proteins; Cytochrome C (cyt C)
products description :
Custom preparations, technical support, bulk quantities and aliquoting available. Cytochrome c, or cyt c, is a small heme protein found loosely associated with the inner membrane of the mitochondrion. It belongs to the cytochrome c family of proteins. It is a highly soluble protein, unlike other cytochromes, with a solubility of about 100 g/L and is an essential component of the electron transport chain, where it carries one electron. It is capable of undergoing oxidation and reduction, but does not bind oxygen. It transfers electrons between Complexes III and IV. In humans, cytochrome c is encoded by the CYCS gene. Cytochrome c is suspected to be the functional complex in so called LLLT: Low-level laser therapy. In LLLT, red light and some near infra-red wavelengths penetrate tissue in order to increase cellular regeneration. Light of this wavelength appears capable of increasing activity of cytochrome c, thus increasing metabolic activity and freeing up more energy for the cells to repair the tissue (source Wikipedia).
ncbi acc num :
NP_061820.1
ncbi gb acc num :
NM_018947.5
ncbi mol weight :
11,749 Da
ncbi pathways :
AGE/RAGE Pathway (698754); Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway (105672); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Apoptosis Pathway (198797); Apoptosis Pathway (83060); Apoptosis Pathway (470)
ncbi summary :
This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]
uniprot summary :
CYCS: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Belongs to the cytochrome c family. Protein type: Mitochondrial; Apoptosis; Oxidoreductase; Protein phosphatase, Ser/Thr (non-receptor). Chromosomal Location of Human Ortholog: 7p15.3. Cellular Component: protein phosphatase type 2A complex; mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space; nucleus; cytosol. Molecular Function: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; protein binding; iron ion binding; heme binding; protein serine/threonine phosphatase activity. Biological Process: mitochondrion organization and biogenesis; cellular metabolic process; response to reactive oxygen species; dephosphorylation; apoptosis; organelle organization and biogenesis; cellular respiration; mitochondrial electron transport, cytochrome c to oxygen; DNA fragmentation during apoptosis; caspase activation via cytochrome c; transmembrane transport; mitochondrial electron transport, ubiquinol to cytochrome c. Disease: Thrombocytopenia 4