Thromboplastin, Bovine Lung | MyBioSource MBS173248 product information

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product summary

company name :

MyBioSource

product type :

protein

product name :

Thromboplastin, Bovine Lung

catalog :

MBS173248

quantity :

50000 Units

price :

250 USD

product information

catalog number :

MBS173248

products type :

Protein

products full name :

Thromboplastin, Bovine Lung

products short name :

Thromboplastin

products name syn :

Thromboplastin, Bovine Lung

other names :

thromboplastin; Tissue factor; tissue factor; coagulation factor III (thromboplastin, tissue factor); Coagulation factor III; Thromboplastin; CD_antigen: CD142

other gene names :

F3; F3; TF; TFA; CD142; TF

uniprot entry name :

TF_HUMAN

sequence length :

295

purity :

Purified

form :

Lyophilized

storage stability :

At -20 degree C

other info1 :

Source: Bovine Lung. Moisture: 12,000 U/mg protein

other info2 :

Reconstitution: 0.9% sodium chloride. Recertification: 1 year. pH: 6.5 - 7.5. Moisture Content: < 5.0% (Karl Fischer). Additional Info: All bovine material is collected from USDA approved facilities.

products categories :

Proteins; Antigens; Standards/controls; Native Proteins; Thromboplastin

products description :

Custom preparations, technical support, bulk quantities and aliquoting available. According to published literature thromboplastin substance necessary to the coagulant activity of tissue extracts; also has been referred to as the direct activator of prothrombin and as a substance from plasma, platelets, and tissues that initiates thromboplastic activity in blood coagulation. A substance in blood and tissues which, in the presence of ionized calcium, aids in the conversion of prothrombin to thrombin. Extrinsic and intrinsic thromboplastin are formed as the result of the interaction of different clotting factors; the factors that combine to form extrinsic thromboplastin are not all derived from intravascular sources, whereas those that form intrinsic thromboplastin are.

ncbi gi num :

512466

ncbi acc num :

CAA01438.1

ncbi mol weight :

27,145 Da

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Extrinsic Pathway (106058); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028)

ncbi summary :

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

uniprot summary :

F3: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response. Lung, placenta and pancreas. Belongs to the tissue factor family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p22-p21. Cellular Component: extracellular matrix; extracellular space; cell surface; integral to membrane; plasma membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protease binding; phospholipid binding. Biological Process: caspase activation; activation of blood coagulation via clotting cascade; positive regulation of protein kinase B signaling cascade; activation of plasma proteins during acute inflammatory response; blood coagulation, extrinsic pathway; positive regulation of angiogenesis; positive regulation of positive chemotaxis; cytokine and chemokine mediated signaling pathway; positive regulation of endothelial cell proliferation; blood coagulation; positive regulation of cell migration

size1 :

50000 Units

price1 :

250 USD

size2 :

500000 Units

price2 :

710