catalog number :
MBS173247
products full name :
Myosin Light Chain (MLC), Human Heart
products short name :
Myosin Light Chain
products name syn :
MLC; MYLK3; Myosin Light-Chain Kinase; Myosin Light Chain (MLC), Human Heart - >=95% (SDS-PAGE)
purity :
>= 95% (SDS-PAGE)
storage stability :
At -20 degree C
other info1 :
Source: Human Heart. EC Number: 2.7.11.18
other info2 :
Reconstitution: Neutral pH buffer of choice. Avoid extreme high and low pH. Recertification: 5 years. Protein: 1 mg protein/mg solid (A280 E=0.211)
products categories :
Proteins; Antigens; Standards/controls; Native Proteins; Myosin Light Chain (mlc)
products description :
MyBioSource sells human heart Myosin Light Chain (MLC) for research, life science and diagnostic manufacturing uses. Custom preparations, technical support, bulk quantities and aliquoting available. These enzymes are important in the mechanism of contraction in muscle. Once there is an influx of calcium cations (Ca++) into the muscle, either from the sarcoplasmic reticulum or, more importantly, from the extracellular space, contraction of smooth muscle fibers may begin. First, the calcium will bind to calmodulin. This binding will activate MLCK, which will go on to phosphorylate the myosin light chain at serine residue 19. This will enable the myosin crossbridge to bind to the actin filament and allow contraction to begin (through the crossbridge cycle). Since smooth muscle does not contain a troponin complex like striated muscle does, this mechanism is the main pathway for regulating smooth muscle contraction
ncbi mol weight :
~20,000