Apolipoprotein CIII (ApoCIII), Human - Ultra Pure | MyBioSource MBS173231 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Apolipoprotein CIII (ApoCIII), Human - Ultra Pure

catalog :

MBS173231

quantity :

0.01 mg

price :

175 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173231

products type :

Protein

products full name :

Apolipoprotein CIII (ApoCIII), Human - Ultra Pure

products short name :

Apolipoprotein CIII

products name syn :

ApoC3; Apolipoprotein CIII (Apo CIII), Human - Ultra Pure

other names :

apolipoprotein C-III; Apolipoprotein C-III; apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3; apolipoprotein C-III; Apolipoprotein C3

products gene name :

ApoCIII

other gene names :

APOC3; APOC3; HALP2; APOCIII; Apo-CIII; ApoC-III

uniprot entry name :

APOC3_HUMAN

sequence length :

purity :

>= 99% (SDS-PAGE)

form :

Solution in 10mM tris chloride, 150mM sodium chloride, 0.5mM EDTA, and 0.02% sodium azide, pH 8.0

storage stability :

At -20 degree C. Avoid freeze/thaws

other info1 :

Source: Human Plasma. UNSPSC Code: 51131909. Appearance: Frozen liquid

other info2 :

Recertification: 12-31-2018. Protein: Typically 1.0 mg/mL (Lowry). Handling: Handle as a potentially hazardous substance. Recovery: Microfuge vial before drawing from container.

products categories :

Proteins; Antigens; Standards/controls; Native Proteins; Immunogen; Apolipoprotein Ciii (apo Ciii)

products description :

MyBioSource sells Human Apolipoprotein CIII (ApoCIII/ApoC3) for research and diagnostic manufacturing. Technical support, bulk quantities and aliquoting available. This product is purified from delipidated VLDL (very low density lipoprotein) and is purified through affinity chromotography. Normal plasma concentration of Human Apolipoprotein CIII (Apo-CIII)is 8-15 mg/dL. The physiological role of human Apo-CIII is unclear, although it may inhibit the activation of lipoprotein lipase by Apo-CII.

ncbi gi num :

4557323

ncbi acc num :

NP_000031.1

ncbi gb acc num :

NM_000040.1

ncbi mol weight :

10,852 Da

ncbi pathways :

Chylomicron-mediated Lipid Transport Pathway (106157); Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); HDL-mediated Lipid Transport Pathway (106158); Lipid Digestion, Mobilization, And Transport Pathway (106111); Lipoprotein Metabolism Pathway (106156); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450)

ncbi summary :

Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]

uniprot summary :

APOC3: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles. Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2). HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Belongs to the apolipoprotein C3 family. Protein type: Secreted; Lipid-binding; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 11q23.3. Cellular Component: extracellular space; chylomicron; early endosome; extracellular region. Molecular Function: lipase inhibitor activity; cholesterol binding; phospholipid binding; enzyme regulator activity. Biological Process: response to drug; cholesterol metabolic process; response to peptide hormone stimulus; phototransduction, visible light; regulation of Cdc42 protein signal transduction; lipoprotein metabolic process; cholesterol efflux; G-protein coupled receptor protein signaling pathway; cholesterol homeostasis; reverse cholesterol transport; triacylglycerol metabolic process; negative regulation of lipid catabolic process; phospholipid efflux; lipoprotein transport; triacylglycerol catabolic process; negative regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; triacylglycerol mobilization; negative regulation of lipid metabolic process; retinoid metabolic process; inflammatory response; response to nutrient; negative regulation of fatty acid biosynthetic process. Disease: Apolipoprotein C-iii Deficiency

size1 :

0.01 mg

price1 :

175 USD

size2 :

0.1 mg

price2 :

420

size3 :

0.5 mg

price3 :

1530

more info or order :

MyBioSource product webpage