Troponin T (Tn-T), Human Heart | MyBioSource MBS173201 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Troponin T (Tn-T), Human Heart

catalog :

MBS173201

quantity :

0.025 mg

price :

230 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173201

products type :

Protein

products full name :

Troponin T (Tn-T), Human Heart

products short name :

Troponin T

products name syn :

Troponin T (Tn-T), Human Heart - >=98% (SDS-PAGE)

other names :

troponin T, partial; Troponin T, cardiac muscle; troponin T, cardiac muscle; troponin T2, cardiac; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant); troponin T type 2 (cardiac); Cardiac muscle troponin T; cTnT

products gene name :

Tn-T

other gene names :

TNNT2; TNNT2; CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6; TnTc; cTnT

uniprot entry name :

TNNT2_HUMAN

sequence length :

purity :

>= 98% (SDS-PAGE)

form :

Liquid

storage stability :

At -20 degree C

other info1 :

Source: Human Heart. UNSPSC Code: 51131907

other info2 :

Recertification: 2 years. Protein: >= 0.5 mg/mL (A280)

products categories :

Proteins; Antigens; Standards/controls; Native Proteins; Immunogen; Troponin T (tn-t)

products description :

MyBioSource produces Human Heart Troponin T (Tn-T) for research and manufacturing uses. Custom preparations, technical support, bulk quantities and aliquoting available. MyBioSource specializes in human cardiac markers such as Creatine Kinases, Troponins, and Myoglobin among others, both native and recombinant. Human heart Troponin is a family of proteins (I, T and C) and are found in skeletal and heart muscle fibers; it helps muscles contract. Certain subtypes of human Troponin (human cardiac troponin I and cardiac Troponin T) are very sensitive and specific indicators of damage to the heart muscle myocardium). Troponin are measured in the blood to differentiate between unstable angina and myocardial infarction (heart attack) in patients with chest pain. A patient who had suffered from a myocardial infarction would have an area of damaged heart muscle and so would have elevated human cardiac Troponin levels in the blood.

ncbi gi num :

547043

ncbi acc num :

AAB30956.1

ncbi mol weight :

~35,000

ncbi pathways :

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Cardiac Progenitor Differentiation Pathway (712094); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (106261)

ncbi summary :

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

uniprot summary :

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Motor. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament. Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding. Biological Process: metabolic process; regulation of muscle contraction; atrial cardiac muscle morphogenesis; positive regulation of ATPase activity; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding. Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2

size1 :

0.025 mg

price1 :

230 USD

size2 :

0.1 mg

price2 :

420

size3 :

1 mg

price3 :

1470

more info or order :

MyBioSource product webpage