protein

Thyroxine Binding Globulin (TBG), Human Serum

MBS173193

1 mg

185 USD

Protein

Thyroxine Binding Globulin (TBG), Human Serum

Thyroxine Binding Globulin

Thyroxine Binding Globulin (TBG), Human

thyroxine-binding globulin; Thyroxine-binding globulin; thyroxine-binding globulin; serpin A7; T4-binding globulin; thyroxin-binding globulin; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Serpin A7; T4-binding globulin

SERPINA7; SERPINA7; TBG; TBG

THBG_HUMAN

415

>= 70% (SDS-PAGE)

Lyophilized

2-8 degree C

Source: Human Serum. UNSPSC Code: 51131907

Reconstitution: PBS, pH: >= 7.0 containing 0.15 M NaCl is recommended. Recertification: 3 years. Additional Info: T4: <1 ug/dL, ANS: <1%

Proteins; Antigens; Standards/controls; Native Proteins; Thyroxine Binding Globulin (tbg)

MyBioSource is the leading supplier of Human Thyroxine Binding Globulin (TBG) for research and diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Human Thyroxine Binding Globulin (TBG) is one of three proteins responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3-triiodothyronine (T3) in the bloodstream, along with transthyretin and albumin. TBG has the highest affinity for T4 and T3, but is present in the lowest concentration of the three proteins. Despite the low concentration, it carries the majority of T4 in serum. Due to the very low serum concentration of T4 & T3, TBG is rarely more than 25% saturated with ligand. Unlike transthyretin and albumin, Thyroxin Binding Globulin has a single binding site for T4/T3.

205277441

NP_000345.2

NM_000354.5

55000

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

SERPINA7: Major thyroid hormone transport protein in serum. Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency). Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein- bound iodine but are euthyroid. Belongs to the serpin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: Xq22.2. Cellular Component: extracellular space; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; hormone binding. Biological Process: response to drug; response to peptide hormone stimulus; response to vitamin A; post-embryonic development; aging; response to corticosterone stimulus

1 mg

185 USD

5 mg

360

10 mg

570