Thyroglobulin (Tg), Human Thyroid - High Purity | MyBioSource MBS173188 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Thyroglobulin (Tg), Human Thyroid - High Purity

catalog :

MBS173188

quantity :

1 mg

price :

230 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173188

products type :

Protein

products full name :

Thyroglobulin (Tg), Human Thyroid - High Purity

products short name :

Thyroglobulin

products name syn :

Thyroglobulin (Tg), Human

other names :

thyroglobulin; Thyroglobulin; thyroglobulin; thyroglobulin

products gene name :

other gene names :

TG; TG; TGN; AITD3; Tg

uniprot entry name :

THYG_HUMAN

sequence length :

2768

purity :

>99% (SDS-PAGE)

form :

Lyophilized from 0.2um filtered 20mM ammonium bicarbonate. May contain traces of buffer salts. Appearance: White to off-white powder

storage stability :

2-8 degree C

other info1 :

Source: Human Thyroid Gland. UNSPSC Code: 51131907

other info2 :

Reconstitution: Reconstitute into provided container and centrifuge to ensure full recovery. Use of a phosphate buffer, pH > 7.0 containing 150mM sodium chloride is recommended. Recertification: 3-20-2018. CAS Number: 9010-34-8. Handling: Handle as a potentially hazardous substance. Refer to MSDS on website.

products categories :

Proteins; Antigens; Standards/controls; Native Proteins; Thyroglobulin (tg)

products description :

MyBioSource is the leading supplier of human Thyroglobulin (Tg) for clinical research and diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Thyroglobulin is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland and was referred to as a "colloid". Human Tg is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine. Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against human Thyroglobulin (Tg). Human Thyroglobulin specific antibodies help in the diagnosis of these diseases, but they also may be present in apparently healthy euthyroid individuals. Human Thyroglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer and levels in the blood can also be elevated in cases of Graves disease.

ncbi gi num :

55770862

ncbi acc num :

NP_003226.4

ncbi gb acc num :

NM_003235.4

ncbi mol weight :

660 kDa

ncbi pathways :

Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541); Thyroxine (Thyroid Hormone) Production Pathway (920992)

ncbi summary :

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]

uniprot summary :

TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 8q24. Cellular Component: extracellular space; extracellular region. Molecular Function: hormone activity. Biological Process: regulation of myelination; iodide transport; thyroid gland development; hormone biosynthetic process; signal transduction; thyroid hormone metabolic process. Disease: Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease, Susceptibility To, 3

size1 :

1 mg

price1 :

230 USD

size2 :

10 mg

price2 :

770

more info or order :

MyBioSource product webpage