Prostate Specific Antigen (PSA), Human Semen | MyBioSource MBS173180 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Prostate Specific Antigen (PSA), Human Semen

catalog :

MBS173180

quantity :

0.1 mg

price :

230 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173180

products type :

Protein

products full name :

Prostate Specific Antigen (PSA), Human Semen

products short name :

Prostate Specific Antigen

products name syn :

Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase; Prostate Specific Antigen (PSA), Human Semen - >=96% (SDS-PAGE) - Liquid

other names :

prostate-specific antigen isoform 1 preproprotein; Prostate-specific antigen; prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen; kallikrein-related peptidase 3; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase

products gene name :

KLK3

products gene name syn :

APS; KLK2A1; PSA; hK3

other gene names :

KLK3; KLK3; APS; PSA; hK3; KLK2A1; APS; PSA; Seminin

uniprot entry name :

KLK3_HUMAN

sequence length :

261

purity :

>= 96% (SDS-PAGE, one band corresponding to PSA at 30 kDa)

form :

0.2 micron filtered solution in 0.05M sodium phosphate, 0.15M sodium chloride and 0.09% sodium azide, pH 7.5. Appearance: Clear, colorless liquid

storage stability :

2-8 degree C. Do not Freeze

other info1 :

Source: Human Semen. EC Number: 3.4.21.77. UNSPSC Code: 41116012. Electrophoresis: Single band, lamda electrophoretic mobility. Recertification: 7-24-2017

other info2 :

Protein: 4.2 mg protein/mL (A 280 , E=1.7). Handling: Handle as a potentially hazardous substance. Recovery: Centrifuge briefly to ensure complete recovery.

products categories :

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Prostate Specific Antigen (psa)

products description :

MyBioSource is the leading producer and supplier of Human Prostate Specific Antigen (PSA) protein as a prostate tumor marker for medical research and clinical diagnostic and biomedical manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Prostate-specific antigen (PSA) also known as gamma-seminoprotein or kallikrein-3 is a glycoprotein that in humans is encoded by the KLK3 gene. PSA is produced for the ejaculate where it liquifies the semen in the seminal coagulum and allows sperm to swim freely. PSA is also believed to be instrumental in dissolving the cervical mucous, allowing the entry of sperm.

ncbi gi num :

4502173

ncbi acc num :

NP_001639.1

ncbi gb acc num :

NM_001648.2

uniprot acc num :

P07288

ncbi mol weight :

28,430

ncbi pathways :

Androgen Receptor Signaling Pathway (198806); Coregulation Of Androgen Receptor Activity Pathway (138085); FOXA1 Transcription Factor Network Pathway (137979); Metabolism Of Proteins Pathway (106230); Pathways In Cancer (83105); Prostate Cancer Pathway (755440); Prostate Cancer Pathway (83111); Prostate Cancer Pathway (523); Regulation Of Androgen Receptor Activity Pathway (138027); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)

ncbi summary :

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

uniprot summary :

PSA: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily. Protein type: Secreted; Secreted, signal peptide; Protease; EC 3.4.21.77. Chromosomal Location of Human Ortholog: 19q13.41. Cellular Component: extracellular region; nucleus. Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity. Biological Process: negative regulation of angiogenesis; cellular protein metabolic process; proteolysis

size1 :

0.1 mg

price1 :

230 USD

size2 :

0.5 mg

price2 :

450

size3 :

1 mg

price3 :

600

size4 :

5 mg

price4 :

2380

more info or order :

MyBioSource product webpage