protein

Prealbumin/Transthyretin, Human Plasma

MBS173179

1 mg

175 USD

Protein

Prealbumin/Transthyretin, Human Plasma

Prealbumin

Transthyretin; Thyroxine Binding Prealbumin; ATTR; TBPA; Prealbumin (Transthyretin, TTR), Human Plasma - >=96% (SDS-PAGE)

Transthyretin; Transthyretin; transthyretin; ATTR; carpal tunnel syndrome 1; thyroxine-binding prealbumin; epididymis luminal protein 111; prealbumin, amyloidosis type I; transthyretin; ATTR; Prealbumin; TBPA

TTR

PALB

TTR; TTR; CTS; CTS1; PALB; TBPA; HEL111; HsT2651; PALB

TTHY_HUMAN

147

>= 98% (SDS-PAGE)

Lyophilized powder from 0.02M NH4HCO3. May contain traces of buffer salts.

2-8 degree C. Shipping: Cold Ice Pack

Source: Human Plasma. UNSPSC Code: 51131907

Reconstitution: Use of a phosphate buffer, pH > 7.0 containing 0.15M NaCl is recommended. Advice: Reconstitute into provided container and centrifuge to ensure full recovery. Recertification: 9-30-2016. Advice: Reconstitute into provided container and centrifuge to ensure full recovery. Handling: Handle as a potentially hazardous substance.

Proteins; Antigens; Standards/controls; Native Proteins; Immunogen; Prealbumin (transthyretin; Ttr)

MyBioSource is the leading manufacturer of high purity human plasma Prealbumin/Transthyretin. Custom preparations, technical support, bulk quantities and aliquoting available. Prealbumin levels shows that human prealbumin is very useful as a nutritional predictor of survival in end-stage renal disease patients. Clinical indications for plasma protein assays: human transthyretin in inflammation and malnutrition: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division Committee on Plasma Proteins (C-PP). REF: Clin Chem Lab Med 2007;45:419-26

136464

P02766.1

P02766

Amyloids Pathway (366238); Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Extracellular Matrix Organization Pathway (576262); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Non-integrin Membrane-ECM Interactions Pathway (833810); Retinoid Cycle Disease Events Pathway (771582); Retinoid Metabolism And Transport Pathway (187208); Signal Transduction Pathway (477114); The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway (771585)

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]

TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 18q12.1. Cellular Component: extracellular space; protein complex; cytoplasm; extracellular region. Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; hormone activity. Biological Process: phototransduction, visible light; extracellular matrix organization and biogenesis; retinol metabolic process; transport; retinoid metabolic process. Disease: Hyperthyroxinemia, Dystransthyretinemic; Carpal Tunnel Syndrome; Amyloidosis, Hereditary, Transthyretin-related

1 mg

175 USD

5 mg

480