catalog number :
MBS173176
products full name :
Porcine PROTHOMBIN
products short name :
PROTHROMBIN, Porcine
products name syn :
1H-Pyrrole-3-propanoic acid, 5-(aminomethyl)-4-(carboxymethyl)-
other names :
prothrombin; Prothrombin; prothrombin; serine protease; prothrombin B-chain; coagulation factor II (thrombin)
other gene names :
prothrombin; PT; THPH1; RPRGL2
uniprot entry name :
Q16505_HUMAN
purity :
> 95% pure by SDS-PAGE
form :
20mM Tris-HCI, 0.1M NaCl, pH 7.4
concentration :
1.16 mg/ml
storage stability :
Store at < -20 degree C
products categories :
Animal Proteins; High Purity Protein
products description :
MyBioSource PORCINE PROTHROMBIN available in bulk quantities from 50-500mgs. Custom fills of porcine prothrombin available. Prothrombin is a blood-clotting protein. Injury to a blood vessel produces a signal which triggers the conversion of prothrombin to thrombin. Thrombin is a protein which plays a central role in provoking the assembly of other proteins to form the blood clot. prothrombin consumption test. determines thromboplastin generating capacity, which provides information about the first stage of coagulation. When clotting of a normal blood sample occurs, prothrombin is converted to thrombin, thus there should be little or no prothrombin in the serum after the clot is formed. If, however, there is deficiency of blood coagulation, some of the prothrombin will not be utilized (consumed). Abnormal results of the test are found in deficiencies of the first-stage factors of coagulation (factors VIII and IX), and in the presence of circulating anticoagulants, thrombocytopenia, and any other condition leading to inadequate generation of thromboplastin. Called also serum clot tim.
ncbi acc num :
AAB24476.1
ncbi pathways :
Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Blood Clotting Cascade Pathway (198840); Cell Surface Interactions At The Vascular Wall Pathway (106062); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Common Pathway (106060); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Diabetes Pathways (105902); Disease Pathway (530764)
ncbi summary :
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008]