protein

Prostatic Acid Phosphatase (PAP/ACP), Human - High Purity

MBS173169

100 Units

150 USD

Enzyme

Prostatic Acid Phosphatase (PAP/ACP), Human - High Purity

Prostatic Acid Phosphatase

ACP; PAP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39; Prostatic Acid Phosphatase (ACP, PAP), Human Semen - >=98% (SDS-PAGE) - Lyophilized

acid phosphatase; Lysosomal acid phosphatase; lysosomal acid phosphatase; acid phosphatase 2, lysosomal

ACPP

5'-NT; ACP-3; ACP3; PAP

ACP2; ACP2; LAP; LAP

PPAL_HUMAN

423

>= 98% (SDS-PAGE)

Lyophilized

At -20 degree C

Source: Human Semen. EC Number: 3.1.3.2. Unit Definition: One unit will catalyze the hydrolysis of one micromole of thymolphthalein monophosphate to thymolphthalein and phosphate per minute at pH 5.6 and 37 degree C.

Recertification: 2 years. Protein: > 0.2 mg protein/mg (Coomassie). Contaminants: = 100 U/mg (Dimension Clinical Chemistry System)

Proteins; Protein Antigens; Protein Enzymes; Standards/Controls; Native Proteins; Immunogen

MyBioSource produces human seminal fluid Prostatic Acid Phosphatase (PAP/ACP) for research and bulk IVD diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. MyBioSource has an extensive human semen donor program. Custom Acid Phosphatase purification on donor specific semen is available. What is Human Acid Phosphatase? Human Prostate Acid Phosphatase also known as human prostatic acid phosphatase (PAP, ACP) is alternative marker to Prostate Specific Antigen (PSA) for prostate malignancy. Rape investigations will often include testing for the presence of Human prostatic (prostate) acid phosphatase in vaginal fluid. Human PAP is a phosphatase, a type of enzyme, used to free attached phosphate groups from other molecules during digestion. Acid Phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, Acid Phosphatase has an acid pH optimum below 7.0.

1199524

CAA33542.1

P11117

~100,000

Lysosome Pathway (99052); Lysosome Pathway (96865); Riboflavin Metabolism Pathway (83012); Riboflavin Metabolism Pathway (398)

This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. LAP-deficiencies in mice cause multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures. An enzymatically-inactive allele of LAP in mice exhibited a more severe phenotype than the null allele, and defects included cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

ACP2: Defects in ACP2 are a cause of acid phosphatase deficiency (ACPHD). The clinical features are intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding, and death in early infancy. Lysosomal acid phosphatase is deficient in cultured fibroblasts and multiple tissues. Belongs to the histidine acid phosphatase family. Protein type: Cofactor and Vitamin Metabolism - riboflavin; Phosphatase (non-protein); EC 3.1.3.2; Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 11p11.2 11p12-p11. Cellular Component: lysosomal lumen; membrane; lysosomal membrane; lysosome; integral to membrane. Molecular Function: acid phosphatase activity. Biological Process: dephosphorylation; lysosome organization and biogenesis; skeletal development. Disease: Acid Phosphatase Deficiency

100 Units

150 USD

1000 Units

300

10000 Units

2000