Prostatic Acid Phosphatase (PAP/ACP), Human | MyBioSource MBS173168 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Prostatic Acid Phosphatase (PAP/ACP), Human

catalog :

MBS173168

quantity :

100 Units

price :

125 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173168

products type :

Protein

products full name :

Prostatic Acid Phosphatase (PAP/ACP), Human

products short name :

Prostatic Acid Phosphatase

products name syn :

ACP; PAP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39; Prostatic Acid Phosphatase (ACP, PAP), Human Semen - Lyophilized

other names :

acid phosphatase; Lysosomal acid phosphatase; lysosomal acid phosphatase; acid phosphatase 2, lysosomal

products gene name :

ACPP

products gene name syn :

5'-NT; ACP-3; ACP3; PAP

other gene names :

ACP2; ACP2; LAP; LAP

uniprot entry name :

PPAL_HUMAN

sequence length :

423

purity :

Partially Purified

form :

Lyophilized. Appearance: Off-white powder

storage stability :

At -20 degree C

other info1 :

Source: Human Semen. EC Number: 3.1.3.2. Unit Definition: One unit will catalyze the hydrolysis of one micromole of thymolphthalein monophosphate to thymolphthalein and phosphate per minute at pH 5.6 and 37 degree C. Specific Activity: Typically >= 30 U/mg protein

other info2 :

Solubility: Clear, colorless solution (10 mg/mL saline). Recertification: 3 years. Protein: >= 0.2 protein/mg (Coomassie/Biuret). CAS Number: 9001-77-8. Activity: 5 - 15 U/mg solid (Dimension Clinical Chemistry System)

products categories :

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Prostatic Acid Phosphatase (acp/pap)

products description :

MyBioSource produces human Prostatic Acid Phosphatase (PAP/ACP) for research,life science and diagnostic manufacturing uses. Custom preparations, technical support, bulk quantities and aliquoting available. What is Human Acid Phosphatase? Human Prostate Acid Phosphatase also known as human prostatic acid phosphatase (PAP,ACP) is alternative marker to Prostate Specific Antigen (PSA) for prostate malignancy. Rape investigations will often include testing for the presence of Human prostatic (prostate) acid phosphatase in vaginal fluid. The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels. Human Prostate Acid Phosphatase also known as human prostatic acid phosphatase (PAP, ACP) is alternative marker to prostate specific antigen (PSA) for prostate malignancy. Rape investigations will often include testing for the presence of Human prostatic (prostate) acid phosphatase in vaginal fluid. Human prostatic Acid phosphatase (PAP) is a phosphatase, a type of enzyme, used to free attached phosphate groups from other molecules during digestion. Acid Phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore,Human Acid Phosphatase has an acid pH optimum below 7.0.

ncbi gi num :

1199524

ncbi acc num :

CAA33542.1

uniprot acc num :

P11117

ncbi mol weight :

~100,000

ncbi pathways :

Lysosome Pathway (99052); Lysosome Pathway (96865); Riboflavin Metabolism Pathway (83012); Riboflavin Metabolism Pathway (398)

ncbi summary :

This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. LAP-deficiencies in mice cause multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures. An enzymatically-inactive allele of LAP in mice exhibited a more severe phenotype than the null allele, and defects included cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

uniprot summary :

ACP2: Defects in ACP2 are a cause of acid phosphatase deficiency (ACPHD). The clinical features are intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding, and death in early infancy. Lysosomal acid phosphatase is deficient in cultured fibroblasts and multiple tissues. Belongs to the histidine acid phosphatase family. Protein type: EC 3.1.3.2; Motility/polarity/chemotaxis; Phosphatase (non-protein); Cofactor and Vitamin Metabolism - riboflavin; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11p11.2 11p12-p11. Cellular Component: lysosomal lumen; membrane; lysosomal membrane; lysosome; integral to membrane. Molecular Function: acid phosphatase activity. Biological Process: dephosphorylation; lysosome organization and biogenesis; skeletal development. Disease: Acid Phosphatase Deficiency

size1 :

100 Units

price1 :

125 USD

size2 :

1000 Units

price2 :

275

size3 :

5000 Units

price3 :

950

more info or order :

MyBioSource product webpage