Neuron Specific Enolase (NSE), Human Brain | MyBioSource MBS173164 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Neuron Specific Enolase (NSE), Human Brain

catalog :

MBS173164

quantity :

0.025 mg

price :

165 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173164

products type :

Protein

products full name :

Neuron Specific Enolase (NSE), Human Brain

products short name :

Neuron Specific Enolase

products name syn :

2-Phospho-D-glycerate hydro-lyase; NSE; Enolase 2; Gamma-enolase; Neuron Specific Enolase (NSE), Human Brain - >=96% (SDS-PAGE)

other names :

neuron-specific enolase; Gamma-enolase; gamma-enolase; neural enolase; neuron-specific enolase; 2-phospho-D-glycerate hydro-lyase; enolase 2, gamma, neuronal; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase; NSE

products gene name :

ENO2

products gene name syn :

NSE

other gene names :

Eno2; ENO2; NSE; RNEN3; NSE

uniprot entry name :

ENOG_HUMAN

sequence length :

434

purity :

> 96% (SDS-PAGE)

form :

Frozen solution in 0.01M NaH2PO4 pH 7.4 containing 0.15M NaCl and 0.005M MgSO4

storage stability :

At -20 degree C short term, -60 degree C long term

other info1 :

Source: Human Brain. EC Number: 4.2.1.11. Cas No: 9014-08-8. Appearance: Clear, colorless frozen liquid

other info2 :

Recertification: 7-18-2017. Protein: 2.58 mg/mL . CAS Number: 2598556. Activity: => 60 U/mg. Note: Avoid freeze thaw cycles.

products categories :

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Immunogen; Neuron Specific Enolase (nse)

products description :

MyBioSource is the leading supplier of human brain Human Neuron Specific Antigen (NSE) for clinical research and diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Associated Tumor Types: Small-Cell Carcinoma Neuroendocrine Tumor Breast Cancer. According to current literature, NSE is a glycolytic enzyme that catalyzes the conversion of phosphoglycerate to phosphoenol pyruvate and is present in neurons, neuroendocrine cells, and amine precursor uptake and decarboxylation (APUD) cells. Neuron-specific enolase (NSE) is a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue, and was later shown to be present in APUD (amine precursor uptake and decarboxylation) cells and neurons of the diffuse neuroendocrine system but not in other peripheral cells. NSE is a valuable tumor marker for cancers of neuroendocrine origin, especially for small-cell lung cancer and neuroblastoma. Elevated concentrations are observed in patients with neuroblastoma, pancreatic islet cell carcinoma, medullary thyroid carcinoma, pheochromocytoma, and other neuroendocrine tumors as well as in certain benign conditions. NSE levels are frequently increased in patients with SCLC and infrequently in patients with non-SCLC. NSE has therefore been used to monitor disease progression and management in SCLC.

ncbi gi num :

2465396

ncbi acc num :

AAB72088.1

uniprot acc num :

P09104

ncbi mol weight :

~45,000

ncbi pathways :

Biosynthesis Of Amino Acids Pathway (791250); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (816129); Carbon Metabolism Pathway (817567); Disease Pathway (1121849); Gluconeogenesis Pathway (1120902); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (434661); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (468196); Glucose Metabolism Pathway (1120900); Glycogen Storage Diseases Pathway (1121904)

ncbi summary :

catalyzes the interconversion of 2-phosphoglycerate to phosphoenolpyruvate; may play a role in glycolysis [RGD, Feb 2006]

uniprot summary :

ENO2: an enzyme with 2-phospho-D-glycerate hydro-lyase activity. One of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. Protein type: Lyase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11. Chromosomal Location of Human Ortholog: 12p13. Cellular Component: extracellular space; photoreceptor inner segment; phosphopyruvate hydratase complex; plasma membrane; perikaryon; cytosol. Molecular Function: magnesium ion binding; phosphopyruvate hydratase activity. Biological Process: glycolysis; carbohydrate metabolic process; glucose metabolic process; pathogenesis; gluconeogenesis

size1 :

0.025 mg

price1 :

165 USD

size2 :

0.1 mg

price2 :

285

size3 :

1 mg

price3 :

1060

more info or order :

MyBioSource product webpage