Myeloperoxidase (MPO), Human Neutrophil | MyBioSource MBS173163 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Myeloperoxidase (MPO), Human Neutrophil

catalog :

MBS173163

quantity :

0.1 mg

price :

300 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173163

products type :

Protein

products full name :

Myeloperoxidase (MPO), Human Neutrophil

products short name :

[Myeloperoxidase]

products name syn :

[MPO; Myeloperoxidase Antigen (MPO), pANCA - Human - >=96% (SDS-PAGE) - Lyophilized]

other names :

[myeloperoxidase; Myeloperoxidase; myeloperoxidase; myeloperoxidase]

other gene names :

[MPO; MPO; MPO]

uniprot entry name :

PERM_HUMAN

host :

Human Neutrophils

sequence length :

745

purity :

>= 96% (SDS-PAGE)

form :

Powder, Lyophilized from sodium acetate, pH 6.0

storage stability :

Store at -20°C. Protect from moisture. Shipping: Ships with cold packs

other info1 :

Appearance: Light green powder. Unit Definition: One unit of Myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25°C. Activity: 150 units/vial. Specific Activity: 1230 units/mg protein. Rz: 0.83 (A 430 /A 280

other info2 :

Solubility: H2O soluble. RZ Value: >= 0.8 (A 430 /A 280 ). Protein: >= 0.10mg protein/vial, E 0.1% 430nm =1.19). CAS Number: 9003-99-0. EC Number: 1.11.2.2. Handling: Handle as a potentially hazardous substance. Recovery: Microfuge vial before drawing from container.

products categories :

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Immunogen; Myeloperoxidase (mpo) Antigen

products description :

MyBioSource is the largest primary manufacturer of Myeloperoxidase (MPO) enzymes for medical research and diagnostic manufacturing globally. Custom preparations, technical support, bulk quantities and aliquoting available. Rz is an abbreviation for Reinheitszahl (purity number). It is the ratio of absorbance at 430 nm (heme)/ 280 nm (total protein). It is a measure of the purity of the enzyme. Anything above 0.8 is highly pure. MPO is a peroxidase enzyme occurs the most in neutrophil granulocytes (a subtype of white blood cells). It is a lysosomal protein stored in azurophilic granules of the neutrophil. Myeloperoxidase has a green heme pigment and is found in pus and some forms of mucus. It is recognized as an important factor in many inflammatory diseases such as cardiovascular and neurological diseases. MPO-specific imaging agents would thus be highly useful to diagnose early disease, monitor disease progression, and quantify treatment effects.

ncbi gi num :

188658

ncbi acc num :

AAA59863.1

uniprot acc num :

P05164

ncbi pathways :

C-MYB Transcription Factor Network Pathway (138073); Folate Metabolism Pathway (198833); IL23-mediated Signaling Events Pathway (138000); Phagosome Pathway (153910); Phagosome Pathway (153859); Selenium Pathway (198825); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987); Vitamin B12 Metabolism Pathway (920974); Amb2 Integrin Signaling Pathway (137945)

ncbi summary :

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

uniprot summary :

MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 1.11.2.2; Oxidoreductase. Chromosomal Location of Human Ortholog: 17q23.1. Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule. Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding. Biological Process: respiratory burst during defense response; response to food; removal of superoxide radicals; hydrogen peroxide catabolic process; response to mechanical stimulus; response to yeast; response to lipopolysaccharide; defense response; response to oxidative stress; defense response to fungus; negative regulation of apoptosis; aging. Disease: Myeloperoxidase Deficiency; Alzheimer Disease

size1 :

0.1 mg

price1 :

300 USD

size2 :

1 mg

price2 :

745

more info or order :

MyBioSource product webpage