protein

Myeloperoxidase (MPO) Antigen, Human Neutrophil - pANCA

MBS173160

0.025 mg

175 USD

Protein

Myeloperoxidase (MPO) Antigen, Human Neutrophil - pANCA

Myeloperoxidase

MPO; pANCA; Myeloperoxidase Antigen (MPO), pANCA - Human - >=96% (SDS-PAGE) - Liquid

myeloperoxidase; Myeloperoxidase; myeloperoxidase; myeloperoxidase

Mpo; Mpo; mKIAA4033; MPO

PERM_MOUSE

718

>= 96% (SDS-PAGE)

Liquid. Appearance: Clear, greenish Liquid

2-8 degree C

Source: Human Neutrophils. EC Number: 1.11.2.2. Unit Definition: One unit of Myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 degree C. Specific Activity: >= 1,000 U/mg protein

RZ Value: >= 0.8 (A 430 /A 280 ). Recertification: 2 years. Protein: 1.0 - 2.0 mg/mL (A 280 , E 0.1% =1.45). CAS Number: 9003-99-0. Activity: >= 1,000 U/mL

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Immunogen; Myeloperoxidase (mpo) Antigen; Panca

MyBioSource is the largest primary manufacturer of Myeloperoxidase (MPO) enzymes for medical research and diagnostic manufacturing globally. Custom preparations, technical support, bulk quantities and aliquoting available. Rz is an abbreviation for Reinheitszahl (purity number). It is the ratio of absorbance at 430 nm (heme)/ 280 nm (total protein). It is a measure of the purity of the enzyme. Anything above 0.8 is highly pure. MPO is a peroxidase enzyme occurs the most in neutrophil granulocytes (a subtype of white blood cells). It is a lysosomal protein stored in azurophilic granules of the neutrophil. Myeloperoxidase has a green heme pigment and is found in pus and some forms of mucus. It is recognized as an important factor in many inflammatory diseases such as cardiovascular and neurological diseases. MPO-specific imaging agents would thus be highly useful to diagnose early disease, monitor disease progression, and quantify treatment effects.

226823250

NP_034954.2

NM_010824.2

P05164

81,182 Da

Phagosome Pathway (153914); Phagosome Pathway (153859); Transcriptional Misregulation In Cancer Pathway (523020); Transcriptional Misregulation In Cancer Pathway (522987); Phosphate Acquisition II Pathway (542835)

MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 1.11.2.2; Oxidoreductase. Chromosomal Location of Human Ortholog: 17q23.1. Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule. Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding. Biological Process: respiratory burst during defense response; response to food; removal of superoxide radicals; hydrogen peroxide catabolic process; response to mechanical stimulus; defense response; response to yeast; response to lipopolysaccharide; response to oxidative stress; defense response to fungus; aging; negative regulation of apoptosis. Disease: Myeloperoxidase Deficiency; Alzheimer Disease

0.025 mg

175 USD

0.1 mg

250

1 mg

570