catalog number :
MBS173102
products full name :
Haptoglobin, Mouse Serum
products short name :
Haptoglobin
products name syn :
Haptoglobin (Hp), Mouse
other names :
haptoglobin, partial; Haptoglobin-related protein; haptoglobin-related protein; Haptoglobin-related locus; haptoglobin-related protein
other gene names :
HPR; HPR; HP; A-259H10.2
uniprot entry name :
HPTR_HUMAN
purity :
> 90% (SDS-PAGE)
concentration :
Protein Concentration: > 0.5 mg/mL
storage stability :
At -20 degree C
other info1 :
Source: Mouse Serum
other info2 :
Recertification: 2 years
products categories :
Proteins; Antigens; Standards/controls; Native Proteins; Haptoglobin (hp)
products description :
Custom preparations, technical support, bulk quantities and aliquoting available. Haptoglobin (frequently abbreviated as Hp) is a protein in the blood plasma that binds free hemoglobin released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). Haptoglobin is a serum protein that consists of two alpha and two beta chains connected by disulfide bridges. It acts as a hemoglobin scavenger and has been associated with protease inhibitory activity. It is a positive acute phase reactant, the levels of which increase significantly in mice in response to inflammation, tissue injury or disease.
ncbi acc num :
AAA52686.1
ncbi mol weight :
43,078 Da
ncbi pathways :
African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Scavenging Of Heme From Plasma Pathway (771600)
ncbi summary :
This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
uniprot summary :
HPR: a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 16q22.1. Cellular Component: extracellular region. Molecular Function: hemoglobin binding; catalytic activity. Biological Process: receptor-mediated endocytosis; metabolic process