catalog number :
MBS173101
products full name :
Haptoglobin, Porcine Serum
products short name :
Haptoglobin
products name syn :
Haptoglobin (Hp), Porcine Serum
other names :
haptoglobin, partial; Haptoglobin-related protein; haptoglobin-related protein; Haptoglobin-related locus; haptoglobin-related protein
other gene names :
HPR; HPR; HP; A-259H10.2
uniprot entry name :
HPTR_HUMAN
purity :
>= 90% (SDS-PAGE, bands at 10 and 30kDa indicative of alpha and beta subunits)
form :
Frozen solution in phosphate buffered saline with 0.05% sodum azide
storage stability :
At -20 degree C. Avoid freeze/thaw. Shipping: Dry Ice
app notes :
Application: Research, Life Science, Diagnostic Manufacturing, ELISA
other info1 :
Source: Fresh frozem porcine serum
other info2 :
Recertification: 2 years. Protein: 11.4 mg/ml (E 1mg/ml 280nm = 1.56)
products categories :
Proteins; Antigens; Standards/controls; Native Proteins; Haptoglobin (hp)
products description :
Custom preparations, technical support, bulk quantities and aliquoting available. Haptoglobin (frequently abbreviated as Hp) is a protein in the blood plasma that binds free hemoglobin released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). Development of an enzyme immuno assay for the determination of porcine haptoglobin in various body fluids: testing the significance of meat juice measurements for quality monitoring programs. ref:Veterinary Immunology and Immunopathology, Volume 96, Issues 1-2, 15 November 2003, Pages 73-82
ncbi acc num :
AAA52686.1
ncbi mol weight :
43,078 Da
ncbi pathways :
African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Scavenging Of Heme From Plasma Pathway (771600)
ncbi summary :
This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
uniprot summary :
HPR: a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 16q22.1. Cellular Component: extracellular region. Molecular Function: hemoglobin binding; catalytic activity. Biological Process: receptor-mediated endocytosis; metabolic process