catalog number :
MBS173095
products full name :
Gamma-Glutamyl Transferase (gGT), Human Liver
products short name :
gamma-Glutamyl Transferase
products name syn :
Gamma-Glutamyltranspeptidase; Gamma-Glutamyl Transpeptidase; gGT; gamma-GT; GGTP; Gamma-Glutamyl Transferase (gGT), Human - Lyophilized
other names :
gamma-glutamyltransferase, partial; Gamma-glutamyltransferase; gamma-glutamyltranspeptidase 1; glutathione hydrolase 1; leukotriene-C4 hydrolase; gamma-glutamyltransferase 1; Gamma-glutamyltransferase
other gene names :
GGT1; GGT; GGT; GTG; CD224; GGT 1; D22S672; D22S732; N/A
uniprot entry name :
Q9UEN8_HUMAN
specificity :
Liver damage or disease
form :
Lyophilized. Appearance: Tan Powder
storage stability :
At -20 degree C
other info1 :
Source: Human Liver. EC Number: 2.3.2.2. UNSPSC Code: 51131907. Unit Definition: One unit will catalyze the transfer of one micromole of the glutamyl moiety from gamma-glutamyl-3-carboxy-4-nitranilide to glyclglycine per minute at 37 degree C. Specific Activity: > 5 U/mg protein
other info2 :
Recertification: 2 years. Protein: >= 0.1 mg protein/mg (Coomassie). Contaminants: ALP: 9046-27-9. Activity: > 1 U/mg (Dimension Clinical Chemistry System)
products categories :
Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Gamma-glutamyl Transferase (ggt)
products description :
MyBioSource is the leading manufacturer of human gamma Glutamyltransferase/gamma-Glutamyl Transpeptidase (gGT/GGTP). Bulk quantities are available from 50,000 unit single lot sizes. Custom preparations, technical support, bulk quantities and aliquoting available. Clinical Significance: Detection of liver disease, obstructive jaundice, cholangitis, infectious hepititus, and cholecystitis. gamma-Glutamyltransferase (gGT/GGTP) test is used to detect diseases of the liver, bile ducts, and kidney; and to differentiate liver or bile duct (hepatobiliary) disorders from bone disease. The liver stores fuel from food, makes proteins, helps remove poisons and toxins, and produces bile, a digestive fluid that helps the body absorb fat. The gallbladder stores bile until it's needed. Testing for GGT evaluates diseases of the liver, gallbladder, and bile ducts (tubes that carry bile from the liver to the gallbladder and intestine). It also can be used to check for liver damage related to ingestion of toxic substances or alcohol abuse.
ncbi acc num :
CAA07487.1
ncbi mol weight :
5,296 Da
ncbi pathways :
Aflatoxin Activation And Detoxification Pathway 1127511!!Arachidonic Acid Metabolism Pathway 82991!!Arachidonic Acid Metabolism Pathway 685553!!Arachidonic Acid Metabolism Pathway 366!!Biological Oxidations Pathway 105698!!Cyanoamino Acid Metabolism Pathway 82970!!Cyanoamino Acid Metabolism Pathway 339!!Defective ACY1 Causes Encephalopathy Pathway 1127638!!Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway 1127639!!Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway 1127658
ncbi summary :
The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]