Gamma-glutamyl Transferase (gGT), Porcine Kidney | MyBioSource MBS173094 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Gamma-glutamyl Transferase (gGT), Porcine Kidney

catalog :

MBS173094

quantity :

100 Units

price :

200 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173094

products type :

Protein

products full name :

Gamma-glutamyl Transferase (gGT), Porcine Kidney

products short name :

gamma-Glutamyl Transferase

products name syn :

Gamma-Glutamyltranspeptidase; Gamma-Glutamyl Transpeptidase; gGT; gamma-GT; GGTP; Gamma-Glutamyl Transferase (gGT), Porcine Kidney

other names :

Gamma-glutamyltranspeptidase 1; gamma-glutamyltranspeptidase 1; gamma-glutamyltransferase 1; Gamma-glutamyltransferase 1; Glutathione hydrolase 1 (EC:3.4.19.13); Leukotriene-C4 hydrolase (EC:3.4.19.14); CD_antigen: CD224Cleaved into the following 2 chains:Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain

products gene name :

GGT1

products gene name syn :

GGT5

other gene names :

GGT1; GGT1; GGT; GTG; CD224; GGT 1; D22S672; D22S732; GGT; GGT 1

uniprot entry name :

GGT1_HUMAN

sequence length :

225

specificity :

Liver damage or disease

purity :

Purified

form :

Solid , lyophilized from tris-acetate buffer, pH 8.0 with magnesium chloride and zinc chloride. Appearance: White/Tan powder

storage stability :

At -20 degree C

other info1 :

Source: Porcine Kidney. EC Number: 2.3.2.2. Unit Definition: One unit will catalyze the transfer of one micromole of the glutamyl moiety from gamma-glutamyl-3-carboxy-4-nitranilide to glycylglycine per minute at 37 degree C. Specific Activity: 40 U/mg protein (OD 280). 99 U/mg (Coomassie)

other info2 :

Recertification: 3 years. Protein: 0.9 mg protein/mg solid (OD280, Q0030). 0.36 mg protein/mg solid (Coomassie, Q0033). Impurities:: ALKP : 0.3%. CK: <0.01%. GLDH: <0.1%. LDH: <0.01%. SGOT: 0.08%. SGPT: <0.01%. Ammonia: <0.01 umol/mg. Protease: <0.001 OD/8 minutes. CAS Number: 9046-27-9. Activity: 36 U/mg (Dimension Clinical Chemistry System)

products categories :

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Gamma-glutamyl Transferase (ggt)

products description :

MyBioSource is the largest manufacturer of porcine kidney Gamma-glutamyl Transferase (gGT/GGTP) for research and diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Detection of liver disease, obstructive jaundice, cholangitis, infectious hepititus, and cholecystitis. gamma-Glutamyltransferase (gGT/GGTP) test is used to detect diseases of the liver, bile ducts, and kidney; and to differentiate liver or bile duct (hepatobiliary) disorders from bone disease. Our gamma-Glutamyl Transpeptidase (gGT/GGTP) is used in multi-analyte clinical chemistry controls and calibrators for major IVD manufacturers around the world.

ncbi gi num :

73915096

ncbi acc num :

NP_001027537.1

ncbi gb acc num :

NM_001032365.2

ncbi mol weight :

24,080 Da

ncbi pathways :

Aflatoxin Activation And Detoxification Pathway (1124598); Arachidonic Acid Metabolism Pathway (84417); Arachidonic Acid Metabolism Pathway (1125564); Arachidonic Acid Metabolism Pathway (366); Biological Oxidations Pathway (1125652); Cyanoamino Acid Metabolism Pathway (84399); Cyanoamino Acid Metabolism Pathway (339); Defective ACY1 Causes Encephalopathy Pathway (1124597); Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway (1124599); Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway (1124647)

ncbi summary :

The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]

uniprot summary :

GGT1: Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive. Defects in GGT1 are a cause of glutathionuria (GLUTH); also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease. Belongs to the gamma-glutamyltransferase family. 3 isoforms of the human protein are produced by alternative promoter. Protein type: Membrane protein, integral; EC 3.4.19.14; EC 2.3.2.2; Other Amino Acids Metabolism - selenoamino acid; Other Amino Acids Metabolism - taurine and hypotaurine; Lipid Metabolism - arachidonic acid; EC 3.4.19.13; Other Amino Acids Metabolism - glutathione; Other Amino Acids Metabolism - cyanoamino acid; Transferase. Chromosomal Location of Human Ortholog: 22q11.23. Cellular Component: anchored to external side of plasma membrane; extracellular space; plasma membrane; integral to membrane. Molecular Function: protein binding; gamma-glutamyltransferase activity. Biological Process: amino acid metabolic process; glutamate metabolic process; regulation of immune system process; cysteine biosynthetic process; leukotriene metabolic process; proteolysis; leukotriene biosynthetic process; glutathione metabolic process; xenobiotic metabolic process; glutathione catabolic process; regulation of inflammatory response; glutathione biosynthetic process; arachidonic acid metabolic process; spermatogenesis; zymogen activation. Disease: Glutathionuria

size1 :

100 Units

price1 :

200 USD

size2 :

1000 Units

price2 :

300

more info or order :

MyBioSource product webpage