protein

Gamma-Glutamyl Transferase (gGT), Bovine Kidney

MBS173093

1000 Units

145 USD

Protein

Gamma-Glutamyl Transferase (gGT), Bovine Kidney

gamma-Glutamyl Transferase

Gamma-Glutamyltranspeptidase; Gamma-Glutamyl Transpeptidase; gGT; gamma-GT; GGTP; Gamma-Glutamyl Transferase (gGT), Bovine Kidney

Gamma-glutamyltranspeptidase 1; gamma-glutamyltranspeptidase 1; gamma-glutamyltransferase 1; Gamma-glutamyltransferase 1; Glutathione hydrolase 1 (EC:3.4.19.13); Leukotriene-C4 hydrolase (EC:3.4.19.14); CD_antigen: CD224Cleaved into the following 2 chains:Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain

GGT1; GGT1; GGT; GTG; CD224; GGT 1; D22S672; D22S732; GGT; GGT 1

GGT1_HUMAN

225

Liver damage or disease

Purified

Powder, Lyophilized from tris-acetate, pH 7.0. Appearance: Tan Powder

Aliquot and freeze at -20 degree C after reconstitution. Protect from moisture.

Source: Bovine Kidney. EC Number: 2.3.2.2. Unit Definition: One unit will catalyze the transfer of one micromole of the glutamyl moiety from gamma-glutamyl-3-carboxy-4-nitranilide to glycylglycine per minute at 37 degree C. Specific Activity: 29 U/mg protein (Coomassie), 23 U/mg protein (A 280 ). Protein: 0.41 mg protein/mg solid (Coomassie), 0.91mg protein/mg solid (A 280 )

Reconstitution: >= 1 mg /mL in tris buffered saline, 1% BSA, pH 8.0. Recertification: 3 years. Contaminants: ALKP: 0.15%, . CPK: <0.1%, . LDH: 0.1%, SGOT/AST: <0.1%, . SGPT/ALT: <0.01%. CAS Number: 9046-27-9. Activity: 12 U/mg (Dimension Clinical Chemistry System). Ammonia: <0.01 umole/mg

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Gamma-glutamyl Transferase (ggt)

MyBioSource is the largest manufacturer of Bovine Kidney gamma-Glutamyl Transpeptidase, Gamma-glutamyl transferase (gGT/GGTP). Single batch sizes of 100,000 kU. Custom preparations, technical support, bulk quantities and aliquoting available. Detection of liver disease, obstructive jaundice, cholangitis, infectious hepititus, and cholecystitis. gamma-Glutamyltransferase (gGT/GGTP) test is used to detect diseases of the liver, bile ducts, and kidney; and to differentiate liver or bile duct (hepatobiliary) disorders from bone disease. Our Bovine Kidney gamma-Glutamyl Transpeptidase (gGT/GGTP) is used in multi-analyte clinical chemistry controls and calibrators for major IVD manufacturers around the world. We are able to custom purify Bovine Kidney gGT to meet your specific application.

73915096

NP_001027537.1

NM_001032365.2

24,080 Da

Aflatoxin Activation And Detoxification Pathway (1127511); Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553); Arachidonic Acid Metabolism Pathway (366); Biological Oxidations Pathway (105698); Cyanoamino Acid Metabolism Pathway (82970); Cyanoamino Acid Metabolism Pathway (339); Defective ACY1 Causes Encephalopathy Pathway (1127638); Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway (1127639); Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway (1127658)

The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]

GGT1: Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive. Defects in GGT1 are a cause of glutathionuria (GLUTH); also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease. Belongs to the gamma-glutamyltransferase family. 3 isoforms of the human protein are produced by alternative promoter. Protein type: Other Amino Acids Metabolism - taurine and hypotaurine; Other Amino Acids Metabolism - glutathione; EC 2.3.2.2; Other Amino Acids Metabolism - selenoamino acid; Transferase; Membrane protein, integral; EC 3.4.19.14; Other Amino Acids Metabolism - cyanoamino acid; Lipid Metabolism - arachidonic acid; EC 3.4.19.13. Chromosomal Location of Human Ortholog: 22q11.23. Cellular Component: anchored to external side of plasma membrane; extracellular space; plasma membrane; integral to membrane. Molecular Function: protein binding; gamma-glutamyltransferase activity. Biological Process: amino acid metabolic process; glutamate metabolic process; regulation of immune system process; cysteine biosynthetic process; leukotriene metabolic process; proteolysis; leukotriene biosynthetic process; glutathione metabolic process; xenobiotic metabolic process; regulation of inflammatory response; glutathione catabolic process; glutathione biosynthetic process; arachidonic acid metabolic process; spermatogenesis; zymogen activation. Disease: Glutathionuria

1000 Units

145 USD

10000 Units

420

25000 Units

800

100000 Units

2235