Alanine Aminotransferase (ALT, GPT), Human Liver | MyBioSource MBS173088 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Alanine Aminotransferase (ALT, GPT), Human Liver

catalog :

MBS173088

quantity :

100 Units

price :

205 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173088

products type :

Protein

products full name :

Alanine Aminotransferase (ALT, GPT), Human Liver

products short name :

[Alanine Aminotransferase]

products name syn :

[Glutamate Pyruvate Transaminase; Alanine Transaminase; serum glutamic-pyruvic transaminase; SGPT; GPT; ALT; ALAT; Glutamate Pyruvate Transaminase (GPT, ALT), Human Liver - Liquid]

other names :

[glutamate pyruvate transaminase; Alanine aminotransferase 1; alanine aminotransferase 1; GPT 1; glutamic-alanine transaminase 1; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1; glutamate pyruvate transaminase 1; glutamic-pyruvate transaminase (alanine aminotransferase); Glutamate pyruvate transaminase 1; GPT 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1]

other gene names :

[GPT; GPT; AAT1; ALT1; GPT1; AAT1; GPT1; ALT1; GPT 1]

uniprot entry name :

ALAT1_HUMAN

sequence length :

496

specificity :

Liver damage or disease

purity :

Purified

form :

Suspension in tris-buffered 1.8 M ammonium sulfate, pH 7.5

storage stability :

2-8 degree C. Do not freeze

other info1 :

Source: Human Liver. EC Number: 2.6.1.2. UNSPSC Code: 51131907. Activity: 700 U/mL (Dimension@ Clinical Chemistry System). Unit Definition: One unit will catalyze the transamination of one micromole of L-alanine to alphaketoglutarate, forming L-glutamate and pyruvate, per minute at 37°C and pH 7.4. Protein: 24 mg/mL (Coomassie). Specific Acitivty: 30 units/mg protein. Appearance: Yellow-green suspension. Contaminants: ALP: < or = 0.1%. CK: < or = 0.1%. GGT: < or = 0.1%. GOT/AST: 0.6%. LDH: < or = 0.1%

other info2 :

Recertification: 1 year. Protein: > 0.5 mg protein/mL (Coomassie). Contaminants: CPK, ALP & gGT: 50 U/mL (Dimension Clinical Chemistry System)

products categories :

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Alanine Aminotransferase (alt; Gpt)

products description :

MyBioSource is the leading producer of Human Liver Glutamate Pyruvate Transaminase/Alanine transaminase (GPT/ALT) for medical research and clinical diagnostic assays for diagnosis of liver disease. Custom preparations, technical support, bulk quantities and aliquoting available. Elevated levels of Alanine Transaminase (ALT)often suggest the existence of other medical problems such as alcoholic or viral hepatitis, congestive heart failure, liver damage, biliary duct problems, infectious mononucleosis, or myopathy. Human GPT/ALT is an enzyme that catalyzes the reversible transfer of an amino group from alanine to a-ketoglutarate. It is found in serum and in various bodily tissues but is most commonly associated with the liver. Also called Serum Glutamate Pyruvate Transaminase (SGPT) or Alanine Aminotransferase (ALAT). The alanine aminotransferase (ALT) blood test is typically used to detect liver injury, and is often ordered in conjunction with Aspartate Aminotransferase (AST) or as part of a liver panel to screen for and/or help diagnose liver disease. AST and ALT are considered to be two of the most important tests to detect liver injury, although ALT is more specific than AST. Sometimes AST is compared directly to ALT and an AST/ALT ratio is calculated. This ratio may be used to distinguish between different causes of liver damage.

ncbi gi num :

1763096

ncbi acc num :

AAC51155.1

ncbi mol weight :

~100 kDa

ncbi pathways :

2-Oxocarboxylic Acid Metabolism Pathway (714485); 2-Oxocarboxylic Acid Metabolism Pathway (717400); Alanine And Aspartate Metabolism Pathway (198783); Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Amino Acid Synthesis And Interconversion (transamination) Pathway (106173); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567)

ncbi summary :

This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]

uniprot summary :

GPT: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. Protein type: Transferase; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.2. Chromosomal Location of Human Ortholog: 8q24.3. Cellular Component: cytosol. Molecular Function: alanine transaminase activity; pyridoxal phosphate binding. Biological Process: amino acid biosynthetic process; L-alanine catabolic process

size1 :

100 Units

price1 :

205 USD

size2 :

1000 Units

price2 :

995

more info or order :

MyBioSource product webpage