protein

Complement C4c (C4c), Human Plasma

MBS173069

0.1 mg

150 USD

Protein

Complement C4c (C4c), Human Plasma

Complement Component 4c

C4; Complement Component 4 (C4), >95% (SDS-PAGE) - Liquid

Complement component 4 binding protein, alpha; C4b-binding protein alpha chain; C4b-binding protein alpha chain; proline-rich protein; complement component 4 binding protein, alpha; Proline-rich protein; PRP

C4c

DAMC-258G8.6; C4; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; CO4; CPAMD2; RG; DADB-112B14.11-001; C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2; C4F; CH; CO4; CPAMD3; C4B

C4BPA; C4BPA; PRP; C4BP; C4BP; C4bp; PRP

C4BPA_HUMAN

597

> 95% (SDS-PAGE)

Liquid

At -20 degree C

Western Blot (WB)

Source: Human Plasma

Recertification: 3 years. Protein: >= 1.0 mg/mL (A280 E=0.92)

Proteins; Antigens; Standards/controls; Native Proteins; Complement Component 4 (c4)

MyBioSource sells Human Complement C4 (C4) for research and diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Human Complement proteins: It is thought that the complement system might play a role in many diseases with an immune component, such as Alzheimer's disease, asthma, lupus erythematosus, various forms of arthritis, autoimmune heart disease and multiple sclerosis. Deficiencies of the terminal pathway predispose to both autoimmune disease and infections (particularly meningitis).

67,033 Da

Activation Of C3 And C5 Pathway (106412); Allograft Rejection Pathway (920963); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Immune System Pathway (106386); Initial Triggering Of Complement Pathway (106406); Innate Immune System Pathway (106387); Pertussis Pathway (218111)

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]

C4BPA: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: extracellular space; plasma membrane; extracellular region. Molecular Function: protein binding. Biological Process: negative regulation of complement activation, classical pathway; regulation of complement activation; positive regulation of protein catabolic process; innate immune response; complement activation, classical pathway

0.1 mg

150 USD

1 mg

290

3 mg

600