protein

Ceruloplasmin (CER), Human Plasma

MBS173047

0.1 mg

145 USD

Protein

Ceruloplasmin (CER), Human Plasma

Ceruloplasmin

CP; Ceruloplasmin (Cp), Human - >=95% (SDS-PAGE)

ceruloplasmin, partial; Ceruloplasmin; ceruloplasmin; ceruloplasmin (ferroxidase); Ferroxidase

CER

CP; CP; CP-2

CERU_HUMAN

852

>= 95% (SDS-PAGE)

Lyophilized

At -20 degree C

Source: Human Plasma. EC Number: 232-868-3. UNSPSC Code: 51131907

Reconstitution: De-ionized water. Recertification: 3 years. CAS Number: 9031-37-2

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Ceruloplasmin (cp)

Manufacturer MyBioSource produces human plasma Ceruloplasmin for research and bulk manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Human Ceruloplasmin (CER) is officially known as ferroxidase or iron(II):oxygen oxidoreductase. CER is an enzyme synthesized in the liver containing 8 atoms of copper in its structure. Although Human CERULOPLASMIN (CER) is often considered a copper transport protein, this is not its primary function, just as human hemoglobin is not a carrier of iron, although it contains iron. The main carrier for copper in the plasma of humans is albumin. Ceruloplasmin enzyme (ferroxidase) catalyzes the oxidation of ferrous iron (Fe2+) to ferric iron (Fe3+), therefore assisting in Human Ceruloplasmin enzyme transport in the plasma in association with transferrin, which can only carry iron in the ferric state

180249

AAA51975.1

134000

HIF-1-alpha Transcription Factor Network Pathway (138045); Iron Uptake And Transport Pathway (187191); Metal Ion SLC Transporters Pathway (161066); Porphyrin And Chlorophyll Metabolism Pathway (83021); Porphyrin And Chlorophyll Metabolism Pathway (407); SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (119571)

The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

CP: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP). It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Belongs to the multicopper oxidase family. Protein type: Secreted, signal peptide; Oxidoreductase; EC 1.16.3.1; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Secreted. Chromosomal Location of Human Ortholog: 3q23-q25. Cellular Component: extracellular space; lysosomal membrane; extracellular region. Molecular Function: ferroxidase activity; copper ion binding; chaperone binding. Biological Process: cellular iron ion homeostasis; copper ion transport; transmembrane transport. Disease: Aceruloplasminemia

0.1 mg

145 USD

1 mg

275

10 mg

1175