protein

Cathepsin G, Human Neutrophil

MBS173041

0.1 mg

150 USD

Protein

Cathepsin G, Human Neutrophil

Cathepsin G

Cathepsin G, Human - >=96% (SDS-PAGE) - Liquid

Cathepsin G; Cathepsin G; cathepsin G; cathepsin G

CTSG

CATG; CG

CTSG; CTSG; CG; CATG; CG

CATG_HUMAN

255

>= 96% (SDS-PAGE)

0.2 micron filtered solution in 0.05M sodium acetate, 0.8M sodium chloride, pH 5.5

2-8 degree C

Source: Human Neutrophils. EC Number: 3.4.21.20. Unit Definition: One unit will hydrolyze one micromole of succinyl-alanine-alanine-proline-phenylalanine-p-nitroanilide per minute at 37 degree C and pH 7.5. Specific Activity: Typically > 5 U/mg protein

CAS Number: 56645-49-9 . Appearance: Clear, colorless solution. Activity: 13 u/mL. Unit Definition: One unit will catalyze the hydrolysis of one micromole of succinyl-alanine-alanine-proline-phenylalanine-p-nitroanilide per minute at 37 degree C and pH 7.5. Protein: 1.3 mg/mL (Coomassie). Specific Activity: 9.8 U/mg protein. Reconsitution Advice: Reconsitute into provied container and centrifuge to ensure full recovery.

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Immunogen; Cathepsin G

MyBioSource is the leading supplier of Human Neutrophil Cathepsin G for medical research and diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Human Cathepsin G is a serine protease located in the azurophil granules of neutrophils. Studies have shown that when released from granulocytes, Cathepsin G binds to NK cells and augments NK cytotoxicity through its protease activity.

15680217

AAH14460.1

28,837 Da

ACE Inhibitor Pathway (198763); Activation Of Matrix Metalloproteinases Pathway (576264); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Lysosome Pathway (99052); Lysosome Pathway (96865); Metabolism Of Angiotensinogen To Angiotensins Pathway (685555); Metabolism Of Proteins Pathway (106230)

The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]

CTSG: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride. Belongs to the peptidase S1 family. Protein type: Motility/polarity/chemotaxis; EC 3.4.21.20; Protease. Chromosomal Location of Human Ortholog: 14q11.2. Cellular Component: extracellular matrix; extracellular space; cell surface; extracellular region; plasma membrane; nucleus; secretory granule. Molecular Function: heparin binding; peptidase activity; serine-type endopeptidase activity. Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; positive regulation of immune response; cellular protein metabolic process; response to lipopolysaccharide; immune response; protein processing; proteolysis; angiotensin maturation; defense response to fungus

0.1 mg

150 USD

1 mg

230

10 mg

1175