Butyryl Cholinesterase | MyBioSource MBS173029 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Butyryl Cholinesterase

catalog :

MBS173029

quantity :

1000 Units

price :

215 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173029

products type :

Protein

products full name :

Butyryl Cholinesterase

products short name :

Butyrylcholinesterase

products name syn :

BCHE; BuChE; PCHE; pseudocholinesterase; plasma cholinesterase; Acylcholine acyl-hydrolase; Choline esterase; butyryl; Butyrylcholinesterase (BCHE), Horse Serum

other names :

Butyrylcholinesterase; Cholinesterase; cholinesterase; cholinesterase 1; choline esterase II; pseudocholinesterase; butyrylcholine esterase; cholinesterase (serum) 2; acylcholine acylhydrolase; butyrylcholinesterase; Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; Pseudocholinesterase

products gene name :

BCHE

other gene names :

BCHE; BCHE; E1; CHE1; CHE2; CHE1

uniprot entry name :

CHLE_HUMAN

sequence length :

602

purity :

Purified

form :

Lyophilized powder. Appearance: Light grey powder

storage stability :

At -20 degree C. Shipping: Ships with Dry Ice

other info1 :

Source: Horse Serum. Reaction: An acylcholine + H2O = choline + a carboxylate. EC Number: 3.1.1.8. Unit Definition: One unit will catalyze the hydrolysis of one micromole of butyrylthiocholine to thiocholine and butyrate per minute at 37 degree C. Specific Activity: 820 U/mg protein. Solubility: Clear, light green solution (1.0 ml water per vial)

other info2 :

Recertification: 2-26-2020. Protein: 1.2 mg protein/vial . CAS Number: 2593805. Activity: 1,000 U/vial ( Siemens Dimension (R) Clinical Chemistry System). Reconsitution: reconsititute at 5mg/ml using 0.05M tris chloride, pH7.4.

products categories :

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Butyrylcholinesterase (bche)

products description :

MyBioSource is the leading supplier of horse serum Butyrylcholinesterase (BCHE) for research and diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Butyrylcholinesterase (BCHE, or BuChE), is a non-specific cholinesterase enzyme that hydrolyses many different choline esters. In humans, it is found primarily in the liver and is encoded by the BCHE gene. It is very similar to the neuronal acetylcholinesterase, which is also known as RBC or erythrocyte cholinesterase. The term "serum cholinesterase" is generally used in reference to a clinical test that reflects levels of both of these enzymes in the blood. Assay of butyrylcholinesterase activity in plasma can be used as a liver function test as both hypercholinesterasemia and hypocholinesterasemia indicate pathological processes.

ncbi gi num :

17390312

ncbi acc num :

AAH18141.1

ncbi mol weight :

68,418 Da

ncbi pathways :

Glycerophospholipid Biosynthesis Pathway (645313); Irinotecan Pathway (198905); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Metabolism Of Proteins Pathway (106230); Neuronal System Pathway (106513); Neurotransmitter Clearance In The Synaptic Cleft Pathway (106526); Peptide Hormone Metabolism Pathway (771603); Phospholipid Metabolism Pathway (645312); Synthesis Of PC Pathway (645319)

ncbi summary :

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq, Jul 2008]

uniprot summary :

BCHE: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency). BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Belongs to the type-B carboxylesterase/lipase family. Protein type: Secreted; Hydrolase; EC 3.1.1.8; Nuclear envelope; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3q26.1-q26.2. Cellular Component: membrane; endoplasmic reticulum lumen; nuclear envelope lumen; extracellular region. Molecular Function: identical protein binding; choline binding; enzyme binding; cholinesterase activity; beta-amyloid binding; acetylcholinesterase activity; catalytic activity. Biological Process: response to alkaloid; response to drug; negative regulation of cell proliferation; choline metabolic process; cocaine metabolic process; cellular protein metabolic process; response to folic acid; response to glucocorticoid stimulus; neuroblast differentiation; learning; negative regulation of synaptic transmission

size1 :

1000 Units

price1 :

215 USD

size2 :

5000 Units

price2 :

540

size3 :

15000 Units

price3 :

1295

more info or order :

MyBioSource product webpage