Beta-2 Microglobulin (B2M), Human - High Purity | MyBioSource MBS173024 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Beta-2 Microglobulin (B2M), Human - High Purity

catalog :

MBS173024

quantity :

0.1 mg

price :

150 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173024

products type :

Protein

products full name :

Beta-2 Microglobulin (B2M), Human - High Purity

products short name :

Beta-2 Microglobulin

products name syn :

B2M; BMG; beta-2 Microglobulin (B2M), Human Urine - >=98% (SDS-PAGE) - Lyophilized

other names :

beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; beta-2-microglobulin

products gene name :

B2M

products gene name syn :

CDABP0092; HDCMA22P

other gene names :

B2M; B2M

uniprot entry name :

B2MG_HUMAN

sequence length :

119

purity :

>= 98% (SDS-PAGE)

form :

Lyophilized

storage stability :

2-8 degree C

other info1 :

Source: Human Urine. UNSPSC Code: 51131907

other info2 :

Reconstitution: Phosphate buffered saline, pH >7.0. Recertification: 4 years. Protein: Reported in mg/mL pre-lyophilization (A 280 , E 0.1% 280 nm =1.65)

products categories :

Proteins; Antigens; Standards/controls; Native Proteins; Immunogen; Beta-2 Microglobulin (b2m)

products description :

MyBioSource is the leading producer and supplier of Human Urine Beta-2 Microglobulin (B2M) for use in medical autoimmune research and manufacturing of clinical diagnostic assays. Custom preparations, technical support, bulk quantities and aliquoting available. Serum beta-2 Microglobulin, an endogenous marker for renal function, has been shown to be an independent predictor of mortality in older adults. The characteristics of B2M make it useful as a tumor marker for some blood cell cancers, for detecting kidney damage, and for distinguishing between glomerular and tubular disorders of the kidney. It is not diagnostic for a specific disease, but it gives the doctor additional information about someone's likely prognosis and about the health of their kidneys.

ncbi gi num :

179318

ncbi acc num :

AAA51811.1

uniprot acc num :

P61769

ncbi mol weight :

~11,800

ncbi pathways :

Adaptive Immune System Pathway (366160); Amyloids Pathway (366238); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cytokine Signaling In Immune System Pathway (366171); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550)

ncbi summary :

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

uniprot summary :

B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: Golgi apparatus; extracellular space; focal adhesion; endoplasmic reticulum lumen; extracellular region; Golgi membrane; phagocytic vesicle membrane; membrane; early endosome membrane; cytoplasm; plasma membrane; MHC class I protein complex; external side of plasma membrane. Molecular Function: identical protein binding; protein binding. Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; antigen processing and presentation of peptide antigen via MHC class I; iron ion homeostasis; response to cadmium ion; response to molecule of bacterial origin; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent. Disease: Hypoproteinemia, Hypercatabolic

size1 :

0.1 mg

price1 :

150 USD

size2 :

1 mg

price2 :

230

size3 :

10 mg

price3 :

830

more info or order :

MyBioSource product webpage