protein

Apolipoprotein CI (Apo CI), Human Plasma - Ultra Pure

MBS173022

0.01 mg

200 USD

Protein

Apolipoprotein CI (Apo CI), Human Plasma - Ultra Pure

Apolipoprotein CI

Apo C1; ApoCI; ApoC1; Apolipoprotein CI (Apo CI), Human - Ultra Pure

apolipoprotein C-I; Apolipoprotein C-I; apolipoprotein C-I; apo-CIB; apoC-IB; apolipoprotein C1; apolipoprotein C-I variant I; apolipoprotein C-I; Apolipoprotein C1Truncated apolipoprotein C-I

Apo CI

APOC1; APOC1; Apo-CI; ApoC-I; Apo-CI; ApoC-I

APOC1_HUMAN

83

>= 99% (SDS-PAGE)

Liquid

At -20 degree C

Source: Human Plasma. UNSPSC Code: 51131909

Recertification: 2 years. Protein: > 0.5 mg/mL (Lowry)

Proteins; Antigens; Standards/controls; Native Proteins; Immunogen; Apolipoprotein Ci (apo Ci)

MyBioSource sells Human Apolipoprotein CI (ApoCI/ApoC1) for research and diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Human Apolipoprotein CI (Apo CI) is a lipoprotein with a length of 57 amino acids. Human Apolipoprotein CI (Apo CI) is one of the most positively charged proteins in the human body. Apolipoprotein CI main function is inhibition of CETP, probably by altering the electric charge of HDL molecules. Recent studies have suggested that apoprotein (apo) CI in very low-density lipoprotein (VLDL) plays an important role in causing hypertriglyceridemia independent of apo CIII, which is associated with coronary heart disease (CHD). Apo-CI Lipoprotein has been found to activate LCAT. The normal plasma concentration is 4-7 mg/dL.

4502157

NP_001636.1

NM_001645.3

9,332 Da

Statin Pathway (198852)

The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

APOC1: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Belongs to the apolipoprotein C1 family. Protein type: Secreted; Lipid-binding; Endoplasmic reticulum; Inhibitor; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: chylomicron; endoplasmic reticulum. Molecular Function: phospholipase inhibitor activity; lipase inhibitor activity; phosphatidylcholine binding; fatty acid binding. Biological Process: positive regulation of catalytic activity; cholesterol metabolic process; negative regulation of cholesterol transport; lipoprotein metabolic process; cholesterol efflux; triacylglycerol metabolic process; phospholipid efflux; negative regulation of lipid catabolic process; negative regulation of receptor-mediated endocytosis; negative regulation of lipoprotein lipase activity; lipid metabolic process; negative regulation of lipid metabolic process; regulation of cholesterol transport; negative regulation of fatty acid biosynthetic process

0.01 mg

200 USD

0.1 mg

480

0.25 mg

950