catalog number :
MBS173019
products full name :
Aprotinin, Bovine Lung
products short name :
Aprotinin
products name syn :
Pancreatic Trypsin Inhibitor; Basic Protease Inhibitor; BPI; BPTI; Aprotinin, Bovine Lung
other names :
aprotinin, partial; Pancreatic trypsin inhibitor; pancreatic trypsin inhibitor; aprotinin; basic protease inhibitor; pancreatic trypsin inhibitor<; Aprotinin; Basic protease inhibitor; BPI; BPTI
products gene name syn :
BOS_13313; BPI; BPTI
other gene names :
PTI; BPI; BPI; BPTI; BPTI
uniprot entry name :
BPT1_BOVIN
purity :
> 95% (Native PAGE)
form :
Lyophilized. Appearance: White to off-white powder
storage stability :
At -20 degree C
other info1 :
Source: Bovine Lung
other info2 :
Solubility: Clear and colorless in water and isotonic solutions, basically insoluble in organic solvents. Recertification: 2 years. Protein: >= 0.9 mg protein/mg solid. pH: 5.0 - 7.0. CAS Number: 9087-70-1. Activity: 3.0 - 8.0 TIU/mg solid
products categories :
Proteins; Antigens; Standards/controls; Native Proteins; Aprotinin
products description :
MyBioSource bovine lung Aprotinin is used for the isolation of proteins as well as for biopharmaceutical downstream purification to inhibit undesired proteolytic activity of serine proteases such as trypsin, plasmin, trypsinogen, urokinase, chymotrypsin, kallikrein, elastase and others. Custom preparations, technical support, bulk quantities and aliquoting available. The stability of the Aprotinin molecule is due to the 3 disulfide bonds linking the 6 cysteine members of the chain (Cys5-Cys55, Cys14-Cys38 and Cys30-Cys51). The lysine (15)-alanine (16) sequence on this strongly basic polypeptide represents the active center. A single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities. As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation. This agent also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. Bovine Aprotinin REF: National Cancer Society/bovine/aprotinin.
ncbi acc num :
CAA37967.1
ncbi mol weight :
6511.44