Alpha-2 Macroglobulin (A2M/AMG), Human Plasma | MyBioSource MBS173010 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Alpha-2 Macroglobulin (A2M/AMG), Human Plasma

catalog :

MBS173010

quantity :

1 mg

price :

230 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173010

products type :

Protein

products full name :

Alpha-2 Macroglobulin (A2M/AMG), Human Plasma

products short name :

Alpha-2 Macroglobulin

products name syn :

Alpha-2-M; A2M; AMG; Alpha-2 Macroglobulin (A2M) - >=95% (SDS-PAGE)

other names :

alpha-2-macroglobulin; Alpha-2-macroglobulin; alpha-2-macroglobulin; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

products gene name :

A2MD

products gene name syn :

CPAMD5; FWP007; S863-7

other gene names :

A2M; A2M; A2MD; CPAMD5; FWP007; S863-7; CPAMD5; Alpha-2-M

uniprot entry name :

A2MG_HUMAN

sequence length :

1474

purity :

>96% (SDS-PAGE)

form :

Lyophilized from 0.2um filtered 0.03M Sodium phosphate pH 7.0 with 1mg glycine per 1 mg A2M. Appearance: White Lyophilized powder

storage stability :

2-8 degree C

other info1 :

Source: Human Serum

other info2 :

Reconstitution: Use deionized water is recommended. Recertification: 4 years. Preservatives: 1 mg glycine/mg A2M. Additional Info: 0.2 micron filtered

products categories :

Proteins; Antigens; Standards/controls; Native Proteins; Alpha-2 Macroglobulin (a2m)

products description :

MyBioSource produces human serum Alpha-2 Macroglobulin (A2M) for research and diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. A2M is a large plasma protein found in the blood and is produced by the liver. It is a major component of the alpha-2 band in protein electrophoresis. Levels are increased in nephrotic syndrome, a condition wherein the kidneys start to leak out some of the smaller blood proteins. Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter, inhibiting many proteases, including trypsin, thrombin and collagenase, and is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.

ncbi gi num :

119608996

ncbi acc num :

EAW88590.1

ncbi mol weight :

650,000 - 800,000

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); HDL-mediated Lipid Transport Pathway (106158); Hemostasis Pathway (106028); IL6-mediated Signaling Events Pathway (137932); Intrinsic Pathway (106059)

ncbi summary :

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

uniprot summary :

A2M: Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. Protein type: Inhibitor; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12p13.31. Cellular Component: extracellular region; cytosol. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding. Biological Process: negative regulation of complement activation, lectin pathway; extracellular matrix disassembly; platelet activation; extracellular matrix organization and biogenesis; regulation of small GTPase mediated signal transduction; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway. Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency

size1 :

1 mg

price1 :

230 USD

size2 :

5 mg

price2 :

615

more info or order :

MyBioSource product webpage