Alpha-1-Antitrypsin (A1AT), Human Serum | MyBioSource MBS173006 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Alpha-1-Antitrypsin (A1AT), Human Serum

catalog :

MBS173006

quantity :

1 mg

price :

230 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS173006

products type :

Protein

products full name :

Alpha-1-Antitrypsin (A1AT), Human Serum

products short name :

Alpha-1-Antitrypsin

products name syn :

Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Alpha-1 Antitrypsin (A1AT), Human Serum - >=95% (SDS-PAGE)

other names :

alpha-1-antitrypsin; Alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1Short peptide from AAT; SPAAT

products gene name :

A1AT

other gene names :

SERPINA1; AAT; PI; SPAAT

uniprot entry name :

A1AT_HUMAN

host :

Human plasma

sequence length :

418

purity :

>96% (SDS-PAGE)

form :

Lyophilized from 0.02M NH 4 HCO 3 . May contain traces of buffer salts.

storage stability :

2-8 degree C.

other info1 :

Source: Human Serum. UNSPSC Code: 51131904

other info2 :

Reconstitution: Use of a phosophate buffer, pH>7.0 containing 0.15M NaCI is recommended. Recertification: 2 years. Protein: 16.25 mg.ml (Dispensing solution by A280). Cas No.: 9041-92-3. Aliquots: >=0.025 mg/vial or >=0.1 mg/vial. SDS-PAGE: Shows a band corresponding to Alpha-1-Antitrypsin molecular weight. Reconstitution Advice: Centrifuge briefly prior to opening to ensure full recovery. Reconstitute using deionized water. Handling: Handle as a potentially hazardous substance.

products categories :

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Alpha-1 Antitrypsin (a1at)

products description :

MyBioSource is the leading supplier of human serum Alpha-1-Antitrypsin (A1AT) for medical research and diagnostic manufacturing. Custom preparations, technical support, bulk quantities and aliquoting available. Human alpha 1 Antitrypsin or Human A1-antitrypsin (A1AT), also known as serum trypsin inhibitor, protects tissue from enzymes from inflammatory cells, especially elastase and is present in human blood. Disorders of the enzyme include human alpha-1 antitrypsin deficiency, a hereditary disorder in which lack of Human alpha-1 Antitrypsin AAT (A1AT) leads to uninhibited tissue breakdown during inflammation. Studies indicate that this causes pulmonary emphysema and leads to liver cirrhosis in severe cases. Human alpha-1 antitrypsin protects the lungs from the harmful effects of human neutrophil elastase.

ncbi gi num :

151302818

ncbi acc num :

CAJ15161.1

uniprot acc num :

P01009

ncbi mol weight :

54kDa

ncbi summary :

The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Inhibitor; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 14q32.1. Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; glycoprotein binding. Biological Process: platelet activation; response to chromate; platelet degranulation; response to triglyceride; response to cytokine stimulus; response to lead ion; response to methanol; acute-phase response; response to hypoxia; response to lipopolysaccharide; blood coagulation; response to estradiol stimulus. Disease: Alpha-1-antitrypsin Deficiency; Pulmonary Disease, Chronic Obstructive

size1 :

1 mg

price1 :

230 USD

size2 :

5 mg

price2 :

570

more info or order :

MyBioSource product webpage