catalog number :
MBS173005
products full name :
Alpha Fetoprotein (AFP), Human Cord Serum
products short name :
Alpha Fetoprotein
products name syn :
AFP; a-fetoprotein; alpha-1-fetoprotein; alpha-fetoglobulin; alpha-1-fetoprotein; Alpha-Fetoprotein (AFP), Human - >=99% (SDS-PAGE) - Liquid
other names :
alpha-fetoprotein; Alpha-fetoprotein; alpha-fetoprotein; alpha-fetoglobulin; alpha-1-fetoprotein; alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin
products gene name syn :
FETA; HPAFP
other gene names :
AFP; AFP; AFPD; FETA; HPAFP; HPAFP
uniprot entry name :
FETA_HUMAN
purity :
>= 99% (SDS-PAGE)
form :
0.2 micron filtered liquid in tris buffered saline, pH 7.5 with 0.09% sodium azide. Appearance: Clear, colorless to straw liquid
storage stability :
2-8 degree C. Do not freeze.
tested application :
Western Blot (WB) and Monobind ELISA
other info1 :
Source: Human Cord Serum. Recertification Date: 8-31-2018. Recovery: If small volume, microfuge vial before drawing from container.
other info2 :
Total Protein: 2.0 mg/mL ( E 0.1% 280nm =0.52). Handling: Handle as a potentially hazardous substance. Refer to MSDS. If small volume, microfuge vial before drawing from container. Identity: Confirmed by Western Blot and Monobind ELISA.
products categories :
Proteins; Antigens; Standards/controls; Native Proteins; Immunogen; Alpha-fetoprotein (afp)
products description :
MyBioSource is the leading producer of human cord serum Alpha-Fetoprotein (AFP) for clinical diagnostic manufacturers and research uses. Custom preparations, technical support, bulk quantities and aliquoting available. Alpha Fetoprotein (AFP) is a protein that is normally only produced in the fetus during its development, and its measurement during pregnancy has been useful to detect certain abnormalities. Elevated levels, if found in amniotic fluid, can indicate a developmental defect in the baby, and is a valuable diagnostic tumor marker.
ncbi acc num :
EAX05681.1
ncbi pathways :
Direct P53 Effectors Pathway (137939); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Glucocorticoid Receptor Regulatory Network Pathway (138014); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388)
ncbi summary :
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
uniprot summary :
AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: extracellular space; cytoplasm. Molecular Function: metal ion binding. Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle. Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of