protein

Recombinant Human C-Reactive Protein (rCRP)

MBS172004

0.1 mg

150 USD

Recombinant Protein

Recombinant Human C-Reactive Protein (rCRP)

C-Reactive

r-hCRP; C-Reactive Protein (CRP) - >=95% (SDS-PAGE)

C-reactive protein; C-reactive protein; C-reactive protein; pentraxin 1; C-reactive protein, pentraxin-related

r-CRP

CRP; CRP; PTX1; PTX1

CRP_HUMAN

224

>= 95% (SDS-PAGE)

Liquid

2-8 degree C

Source: E Coli

Recertification: 4 years. Protein: 0.5 - 2.0 mg/mL. Preservatives: 0.05% Sodium Azide. pH: 7.5. CAS Number: 99401-15-7. Additional Info: Recombinant CRP monomar is made of 206 amino acids, has the same amino acid sequence as native CRP.

Recombinant; Proteins; Antigens; Standards/controls; Immunogen; C-reactive Protein (crp)

MyBioSource is a major supplier of recombinant human C-Reactive Protein (rCRP) in bulk and research quantities for research and In Vitro diagnostic manufacturing for finished products. Custom preparations, technical support, bulk quantities and aliquoting available. C-reactive protein (CRP) is produced by hepatocytes as acute phase reactant to respond to inflammation and tissue damage and consists of five identical subunits under physiological conditions to show pentamer structure as member of pentraxin family. The American Heart Association and the Centers for Disease Control and Prevention published a joint scientific statement in 2003 on the use of inflammatory markers in clinical and public health practice. By patented technology pentamerized active recombinant C-Reactive Protein molecule is secreted into culture medium during E.coli fermentation with host cells having human CRP gene, allowing r-hCRP to be excreted without cell lysis. The patented technology specifies only active r-hCRP to be manufactured, which is equivalent to native one originated from human tissues. This product is affinity-purified by use of phosphorylcholine conjugated matrices.

30224

CAA39671.1

P02741

~23,000

Classical Antibody-mediated Complement Activation Pathway (106409); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (106386); Initial Triggering Of Complement Pathway (106406); Innate Immune System Pathway (106387); Selenium Pathway (198825)

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

CRP: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentaxin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q23.2. Cellular Component: extracellular space; growth cone; extracellular region; filopodium. Molecular Function: choline binding; protein binding; protein homodimerization activity; low-density lipoprotein receptor binding; complement component C1q binding; cholesterol binding; virion binding; low-density lipoprotein binding; calcium ion binding. Biological Process: protein polymerization; defense response to Gram-positive bacterium; response to ethanol; negative regulation of vasodilation; wound healing; positive regulation of superoxide release; response to lead ion; acute-phase response; response to hypoxia; opsonization; inflammatory response; complement activation, classical pathway; aging

0.1 mg

150 USD

1 mg

275

10 mg

1615