catalog number :
MBS170668
products full name :
Thyroglobulin (Tg), anti-Human Monoclonal Antibody
products short name :
[Thyroglobulin (Tg)]
products name syn :
[Mouse Monoclonal anti-Human Thyroglobulin Antibody]
other names :
[thyroglobulin; Thyroglobulin; thyroglobulin; thyroglobulin]
products gene name :
[Tg]
other gene names :
[TG; TG; TGN; AITD3; Tg]
purity :
Purified by ion exchange chromatography
form :
Solution in phosphate buffered saline, pH 7.4 with 0.05% sodium azide.
concentration :
1.87mg/ml (E 0.1% 280nm = 1.4)
storage stability :
Store at 2-8°C. Do not freeze. Ships on blue ice.
other info1 :
Immunogen: High purity human Thyroglobulin (Tg)
other info2 :
Pairing Informaton: This may be used as a capture antibody when paired with mouse monoclonal anti-human Thyroglobulin, MBS170669 as the detection antibody. Handling: Handle as a potentially hazardous substance.
products categories :
Antibodies; Monoclonal; Thyroglobulin (tg), Anti-human Monoclonal Antibody
ncbi acc num :
NP_003226.4
ncbi gb acc num :
NM_003235.4
ncbi pathways :
Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541)
ncbi summary :
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
uniprot summary :
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).