ELISA/assay

Mouse Growth Differentiation Factor 11 (GDF11) ELISA Kit

MBS162268

48-Strip-Wells

280 USD

ELISA Kit

Mouse Growth Differentiation Factor 11 (GDF11) ELISA Kit

[Growth Differentiation Factor 11 (GDF11)]

[growth/differentiation factor 11 preproprotein; Growth/differentiation factor 11; growth/differentiation factor 11; growth differentiation factor 11; Bone morphogenetic protein 111 PublicationManual assertion based on opinion iniRef.1"A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos."Gamer L.W., Wolfman N.M., Celeste A.J., Hattersley G., Hewick R., Rosen V.Dev. Biol. 208:222-232(1999) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA].]

[GDF11]

[GDF11; GDF11; BMP11; BMP-11; BMP111 PublicationManual assertion based on opinion iniRef.1; GDF-11; BMP-11]

Mouse

407

Store at 2 to 8 degree C for 6 months.

Typical Testing Data/Standard Curve (for reference only)

Samples: Serum, plasma, cell culture supernates, cell lysates, tissue homogenates. Assay Type: Quantitative Sandwich. Detection Range: 5ng/L - 1000ng/L. Sensitivity: 2.35ng/L

Intra-Assay: CV<8% . Inter-Assay: CV<10%

Intended Uses: This sandwich kit is for the accurate quantitative detection of Mouse Growth Differentiation Factor 11 (also known as GDF11) in serum, plasma, cell culture supernates, cell lysates, tissue homogenates. Principles of the Assay: This kit is an Enzyme-Linked Immunosorbent Assay (ELISA). The plate has been pre-coated with Mouse GDF11 antibody. GDF11 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Mouse GDF11 Antibody is added and binds to GDF11 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated GDF11 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Mouse GDF11. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm

5031613

NP_005802.1

NM_005811.4

O95390

45,091 Da

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]

Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).

48-Strip-Wells

280 USD

96-Strip-Wells

445

5x96-Strip-Wells

1830

10x96-Strip-Wells

3580