protein

VTCN1 Peptide

MBS153856

0.05 mg

140 USD

Blocking Peptide

VTCN1 Peptide

[VTCN1]

[B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291; UNQ659/PRO1291; V-set domain-containing T-cell activation inhibitor 1; Immune costimulatory protein B7-H4; V-set domain containing T cell activation inhibitor 1]

[V-set domain-containing T-cell activation inhibitor 1 isoform 1; V-set domain-containing T-cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7 homolog 4; B7 family member, H4; B7 superfamily member 1; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; immune costimulatory protein B7-H4; V-set domain containing T cell activation inhibitor 1; B7 homolog 4; B7-H4; B7h.5; Immune costimulatory protein B7-H4; Protein B7S1; T-cell costimulatory molecule B7x]

[VTCN1]

[VTCN1; VTCN1; B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291; B7-H4]

VTCN1_HUMAN

282

Liquid

200 ug/mL

Store VTCN1 peptide at -20 degree C, stable for one year.

Blocking (BL)

VTCN1 peptide is used for blocking the activity of VTCN1 antibody (MBS153856).

Species: Human. Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

99028881

NP_078902

NM_024626.3

Q7Z7D3

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480)

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

VTCN1: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p13.1. Cellular Component: integral to membrane; external side of plasma membrane. Molecular Function: receptor binding. Biological Process: response to protozoan; immune system process; positive regulation of T cell proliferation; negative regulation of T cell activation

0.05 mg

140 USD