IL-17RA Antibody | MyBioSource MBS153615 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IL-17RA Antibody

catalog :

MBS153615

quantity :

0.1 mg

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of IL17RA in A20 cell lysate with IL17RA antibody at 1 g/mL.

image 2 :

Immunohistochemistry of IL-17RA in human spleen tissue with IL-17RA antibody at 2.5 g/ml.

image 3 :

Immunofluorescence of IL-17RA in human spleen tissue with IL-17RA antibody at 20 g/ml.

product information

catalog number :

MBS153615

products type :

Antibody

products full name :

IL-17RA Antibody

products short name :

[IL-17RA]

products name syn :

[IL-17RA; CD217; IL17R; CANDF5; CDw217; IL-17RA; hIL-17R; Interleukin-17 receptor A; IL-17 receptor A; interleukin 17 receptor A]

other names :

[interleukin-17 receptor A isoform 1; Interleukin-17 receptor A; interleukin-17 receptor A; IL-17 receptor A; interleukin 17 receptor A; CDw217; CD_antigen: CD217]

products gene name :

[IL17RA]

other gene names :

[IL17RA; IL17RA; CD217; IL17R; CANDF5; CDw217; IL-17RA; hIL-17R; IL17R; IL-17 receptor A; IL-17RA]

uniprot entry name :

I17RA_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

866

specificity :

IL-17RA antibody is human, mouse and rat reactive. Multiple isoforms of IL-17RA are known to exist. This antibody is predicted to not cross-react with other IL-17 receptor subunits.

purity :

IL-17RA Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

IL-17RA antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

IL-17RA antibody can be used for detection of IL-17RA by Western blot at 1 - 2 mug/mL.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunofluorescence (IF)

image4 heading :

Immunohistochemistry (IHC)

image4 description :

Immunohistochemistry of IL-17RA in human spleen tissue with IL-17RA antibody at 2.5 g/ml.

other info1 :

Conjugate: Unconjugated. Immunogen: IL-17RA antibody was raised against an 18 amino acid peptide near the amino terminus of human IL-17RA. Buffer: IL-17RA Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

IL-17RA Antibody: Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes (1). It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F (1,2). IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis (3,4). Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections (5).

ncbi gi num :

23238208

ncbi acc num :

NP_055154

ncbi gb acc num :

NM_014339.6

uniprot acc num :

Q96F46

ncbi mol weight :

Predicted: 95 kDa. Observed: 135 kDa

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL17 Signaling Pathway (920968)

ncbi summary :

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

uniprot summary :

IL17RA: Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Widely expressed. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 22q11.1. Cellular Component: integral to plasma membrane; extracellular region. Molecular Function: protein binding; interleukin-17 receptor activity. Biological Process: cell surface receptor linked signal transduction; positive regulation of interleukin-23 production; cytokine and chemokine mediated signaling pathway. Disease: Candidiasis, Familial, 5

size1 :

0.1 mg

price1 :

375 USD

more info or order :

MyBioSource product webpage