product summary
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company name :
MyBioSource
product type :
antibody
product name :
DTX4 Antibody
catalog :
MBS153511
quantity :
0.1 mg
price :
375 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
image
image 1 :
Western blot analysis of DTX4 in HeLa cell lysate with DTX4 antibody at 1 g/ml.
image 2 :
Immunohistochemistry of DTX4 in human spleen tissue with DTX4 antibody at 5 g/ml.
image 3 :
Immunofluorescence of DTX4 in human spleen tissue with DTX4 antibody at 20 g/ml.
product information
catalog number :
MBS153511
products type :
Antibody
products full name :
DTX4 Antibody
products short name :
[DTX4]
products name syn :
[Deltex 4 E3 ubiquitin ligase; RNF155; deltex 4, E3 ubiquitin ligase]
other names :
[E3 ubiquitin-protein ligase DTX4 isoform 1; E3 ubiquitin-protein ligase DTX4; E3 ubiquitin-protein ligase DTX4; deltex4; deltex 4 homolog; deltex homolog 4; protein deltex-4; RING finger protein 155; deltex 4, E3 ubiquitin ligase; Protein deltex-4; Deltex4; RING finger protein 155]
products gene name :
[DTX4]
other gene names :
[DTX4; DTX4; RNF155; KIAA0937; RNF155; Deltex4]
uniprot entry name :
DTX4_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
619
specificity :
DTX4 antibody is human and mouse reactive. At least two isoforms of DTX4 are known to exist; this antibody will detect both isoforms. DTX4 antibody is predicted to not cross-react with other DTX protein family members.
purity :
DTX4 antibody is affinity chromatography purified via peptide column.
form :
Liquid
concentration :
1 mg/mL
storage stability :
DTX4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
tested application :
ELISA,IF, IHC-P, WB
app notes :
DTX4 antibody can be used for detection of DTX4 by Western blot at 1 - 2 ug/ml. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunofluorescence (IF)
other info1 :
Conjugate: Unconjugated. Immunogen: DTX4 antibody was raised against a 19 amino acid peptide near the center of human DTX4. The immunogen is located within amino acids 230 - 280 of DTX4. Buffer: DTX4 antibody is supplied in PBS containing 0.02% sodium azide.
products description :
The Deltex 4 E3 ubiquitin ligase (DTX4) is a member of a protein family that is involved in Notch signaling and neurogenesis (1). Recent studies have shown that DTX4 is also associated with the innate immune response (2). Following the activation of type I interferon signaling, the Nod-like receptor protein 4 (NLRP4) recruits DTX4 for Lys48-linked polyubiquitination and degradation of the kinase TBK1 (NAK), thereby maintaining immune homeostasis during antiviral innate immunity (2).
ncbi gi num :
148237498
ncbi acc num :
NP_055992
ncbi gb acc num :
NM_015177.1
uniprot acc num :
Q9Y2E6
ncbi mol weight :
Predicted: 68 kDa. Observed: 68 kDa
ncbi pathways :
Activated NOTCH1 Transmits Signal To The Nucleus Pathway (576270); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); Disease Pathway (530764); FBXW7 Mutants And NOTCH1 In Cancer Pathway (771596); IRF3 Mediated Activation Of Type 1 IFN Pathway (576257); IRF3-mediated Induction Of Type I IFN Pathway (833819); Immune System Pathway (106386); Innate Immune System Pathway (106387); Notch Signaling Pathway (198891); Notch Signaling Pathway (83062)
uniprot summary :
DTX4: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Functions as an ubiquitin ligase protein in vivo, mediating Lys48 -linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 6.3.2.-; Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 11q12.1. Cellular Component: cytosol. Molecular Function: zinc ion binding; ligase activity. Biological Process: regulation of interferon type I production; Notch signaling pathway; positive regulation of interferon type I production; protein ubiquitination; innate immune response
size1 :
0.1 mg
price1 :
375 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
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