Alpha-tubulin Antibody | MyBioSource MBS153509 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Alpha-tubulin Antibody

catalog :

MBS153509

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS153509

products type :

Antibody

products full name :

Alpha-tubulin Antibody

products short name :

Alpha-tubulin

products name syn :

Alpha-tubulin Antibody; TUBA2; bA408E5.3; TUBA2; TUBA3D; Alpha-tubulin 2

other names :

tubulin alpha-3C/D chain; Tubulin alpha-3C/D chain; tubulin alpha-3C/D chain; alpha-tubulin 2; tubulin, alpha 2; alpha-tubulin 3C/D; tubulin alpha-2 chain; tubulin, alpha 3c; Alpha-tubulin 2; Alpha-tubulin 3C/D; Tubulin alpha-2 chain

products gene name :

TUBA3C

other gene names :

TUBA3C; TUBA3C; TUBA2; bA408E5.3; TUBA2

uniprot entry name :

TBA3C_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

450

purity :

Alpha-tubulin Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

Alpha-tubulin antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

Tubulin antibody can be used for detection of Tubulin by Western blot at 0.5 and 1 ug/mL. Optimal dilutions for each application to be determined by the researcer.

other info1 :

Conjugate: Unconjugated. Immunogen: Rabbit polyclonal Tubulin antibody was raised against a 16 amino acid peptide near the amino terminus of human Tubulin. Buffer: Alpha-tubulin Antibody is supplied in PBS containing 0.02% sodium azide.

other info2 :

Positive Control: MBS151663

products description :

Alpha-tubulin Antibody: Alpha-tubulin belongs to the tubulin superfamily, which is composed of six distinct families. Along with beta-tubulins, alpha-tubulins are the major components of microtubules. These microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintenance of cell shape. Alpha- and beta-tubulin dimers are assembled to 13 protofilaments that form a microtubule of 22-nm diameter. Tyrosine ligase adds a C-terminal tyrosine to monomeric alpha-tubulin. Assembled microtubules can again be detyrosinated by a cytoskeleton-associated carboxypeptidase. Another post-translational modification of detyrosinated alpha-tubulin is C-terminal polyglutamylation, which is characteristic of microtubules in neuronal cells and the mitotic spindle. Like GAPDH and beta-Actin, this antibody makes an excellent loading control in immunoblots.

ncbi gi num :

17921993

ncbi acc num :

NP_005992

ncbi gb acc num :

NM_006001.2

uniprot acc num :

Q13748

ncbi mol weight :

Predicted: 50 kDa

ncbi pathways :

Chaperonin-mediated Protein Folding Pathway (106242); Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway (106243); Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway (106245); Gap Junction Pathway (83072); Gap Junction Pathway (483); Metabolism Of Proteins Pathway (106230); Parkin-Ubiquitin Proteasomal System Pathway (700638); Pathogenic Escherichia Coli Infection Pathway (83103); Pathogenic Escherichia Coli Infection Pathway (672459); Pathogenic Escherichia Coli Infection Pathway (516)

ncbi summary :

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. [provided by RefSeq, Jul 2008]

uniprot summary :

TUBA3C/D: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Testis specific. Belongs to the tubulin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 13q11. Cellular Component: microtubule; cytoplasm; nucleus. Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton. Biological Process: protein polymerization; de novo posttranslational protein folding; cellular protein metabolic process; protein folding; microtubule-based process

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage