PROM1 Antibody | MyBioSource MBS153507 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PROM1 Antibody

catalog :

MBS153507

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS153507

products type :

Antibody

products full name :

PROM1 Antibody

products short name :

PROM1

products name syn :

PROM1; RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061; Prominin-1; Antigen AC133; Prominin 1

other names :

prominin-1 isoform 1; Prominin-1; prominin-1; hProminin; antigen AC133; prominin-like protein 1; hematopoietic stem cell antigen; prominin 1; Antigen AC133; Prominin-like protein 1; CD_antigen: CD133

products gene name :

PROM1

other gene names :

PROM1; PROM1; RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061; PROML1

uniprot entry name :

PROM1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

865

specificity :

PROM1 antibody is human, mouse and rat reactive. Multiple isoforms of PROM1 are known to exist.

purity :

PROM1 antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

PROM1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

tested application :

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

app notes :

PROM1 antibody can be used for detection of PROM1 by Western blot at 1 - 2 ug/ml. Antibody can also be used for Immunocytochemistry at 2.5 ug/mL. For Immunoflorescence start at 20 ug/mL. User Note: Optimal dilutions for each application to be determined by the researcher.

other info1 :

Conjugate: Unconjugated. Immunogen: PROM1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human PROM1. Buffer: PROM1 Antibody is supplied in PBS containing 0.02% sodium azide.

other info2 :

Positive Control: MBS151729 Jurkat Cell Lysate

products description :

PROM1 is a pentaspan transmembrane glycoprotein that localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation (1). Mutations in this gene have been shown to result in retinitis pigmentosa (2). Expression of this gene is also associated with several types of cancer (3).

ncbi gi num :

5174387

ncbi acc num :

NP_006008

ncbi gb acc num :

NM_006017.2

uniprot acc num :

O43490

ncbi mol weight :

Predicted: 95 kDa. Observed: 97 kDa

ncbi pathways :

Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

ncbi summary :

This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

uniprot summary :

CD133: Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. Interacts with CDHR1 and with actin filaments. Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells. Expressed in adult retina by rod and cone photoreceptor cells. Belongs to the prominin family. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 4p15.32. Cellular Component: stereocilium; extracellular space; photoreceptor outer segment; cell surface; integral to plasma membrane; endoplasmic reticulum; microvillus membrane; apical plasma membrane; plasma membrane; ER-Golgi intermediate compartment; vesicle; brush border. Molecular Function: actinin binding; protein binding; cadherin binding. Biological Process: photoreceptor cell maintenance; retina morphogenesis in camera-type eye. Disease: Macular Dystrophy, Retinal, 2; Stargardt Disease 4; Retinitis Pigmentosa 41; Cone-rod Dystrophy 12

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage